27821-45-0
Chemical Structure
Uridine-5'-diphosphate disodium salt
Synonym(s): UDP disodium salt
- CAS No.: 27821-45-0
- Formula:C9H12N2Na2O12P2
- Molecular Weight:448.12
IUPAC Name: sodium ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen diphosphate
InChIKey: ZQKVPFKBNNAXCE-WFIJOQBCSA-L
SMILES: O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O)(O[Na])=O)(O[Na])=O)O2)NC1=O
Biological Activity: Uridine-5'-diphosphate (UDP) disodium salt is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate disodium salt is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].
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Uridine-5'-diphosphate disodium salt | 99.61% | Uridine-5'-diphosphate (UDP) disodium salt is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate disodium salt is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. | ||||||||||||||||||||
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Uridine-5'-diphosphate disodium salt (Standard) | ≥98% | Uridine-5'-diphosphate (UDP) disodium salt (Standard) is the analytical standard of Uridine-5'-diphosphate disodium salt (HY-W010832). This product is intended for research and analytical applications. Uridine-5'-diphosphate disodium salt is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate disodium salt is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. | ||||||||||||||||||||
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References
- [1]. Jacobson KA, et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89. [Content Brief]
- [2]. Kim B, et al. Uridine 5'-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor. J Immunol. 2011 Mar 15;186(6):3701-9. [Content Brief]
