Uridine triphosphate trisodium salt
Based on 4 publication(s) in Google Scholar
Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors.
For research use only. We do not sell to patients.
- Purity: 96.0%
- CAS No.: 19817-92-6
- Formula: C9H12N2Na3O15P3
- Molecular Weight:550.09
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Uridine triphosphate trisodium salt
MoreAll Endogenous Metabolite Isoforms
MoreAll P2Y Receptor Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Uridine triphosphate (UTP) (0, 10, 100, 250, 500, and 1000 µM; 2, 4, 6, 8, 10, and 12 h) trisodium salt enhances RT4-D6P2T cells migration and wound repair. Uridine triphosphate trisodium salt induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular MMP-2 activation and expression[2].
Uridine triphosphate (UTP) trisodium salt evokes MAPK phosphorylation in a biphasic pattern MAPK phosphorylation, with an early transient phosphorylation 5 min after treatment, and a late and sustained phosphorylation that appeared at 6 h and lasted up to 24 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RT4-D6P2T cells
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Concentration:250 µM
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Incubation Time:5 min, 45 min, 2 h, 6 h, 12 h, 24 h, 48 h
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Result:Induces biphasic MAPK phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (250-300 g; 2-3 months) with myocardial infarction (MI)[3]
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Dosage:0.44 µg/kg 30 min before MI, and 4.4 µg/kg i.v. 24 h prior to MI.
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Administration:i.v.; once
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Result:Reduced infarct size and improves rat heart function after myocardial infarct.
Chemical Information
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CAS No. 19817-92-6
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Appearance Solid
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Molecular Weight 550.09
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Formula C9H12N2Na3O15P3
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(OP(OP([O-])([O-])=O)([O-])=O)(O)=O.[3Na+]
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Synonyms
UTP trisodium salt; Uridine 5'-triphosphate trisodium salt
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity. [Abstract]2025 Jul 10;188(14):3744-3756.e16. PMID: 40345202 -
Life Sci
2023 Sep 1:328:121896. PMID: 37385371 -
Anal Chim Acta
2021 Dec 15:1188:339180. PMID: 34794559
Solvent & Solubility
H2O : 75 mg/mL (136.34 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (181.79 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
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- Italian - IT (393 KB)
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- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6. [Content Brief]
[2]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998. [Content Brief]
[3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.8179 mL | 9.0894 mL | 18.1788 mL | 45.4471 mL |
| 5 mM | 0.3636 mL | 1.8179 mL | 3.6358 mL | 9.0894 mL | |
| 10 mM | 0.1818 mL | 0.9089 mL | 1.8179 mL | 4.5447 mL | |
| 15 mM | 0.1212 mL | 0.6060 mL | 1.2119 mL | 3.0298 mL | |
| 20 mM | 0.0909 mL | 0.4545 mL | 0.9089 mL | 2.2724 mL | |
| 25 mM | 0.0727 mL | 0.3636 mL | 0.7272 mL | 1.8179 mL | |
| 30 mM | 0.0606 mL | 0.3030 mL | 0.6060 mL | 1.5149 mL | |
| 40 mM | 0.0454 mL | 0.2272 mL | 0.4545 mL | 1.1362 mL | |
| 50 mM | 0.0364 mL | 0.1818 mL | 0.3636 mL | 0.9089 mL | |
| 60 mM | 0.0303 mL | 0.1515 mL | 0.3030 mL | 0.7575 mL | |
| 80 mM | 0.0227 mL | 0.1136 mL | 0.2272 mL | 0.5681 mL | |
| 100 mM | 0.0182 mL | 0.0909 mL | 0.1818 mL | 0.4545 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Uridine triphosphate trisodium salt Related Classifications
HY-W013093 Related Classifications
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