1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Uridine triphosphate

Uridine triphosphate (Synonyms: UTP; Uridine 5'-triphosphate)

Cat. No.: HY-107372 Purity: >98.0%
Handling Instructions

Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

For research use only. We do not sell to patients.

Uridine triphosphate Chemical Structure

Uridine triphosphate Chemical Structure

CAS No. : 63-39-8

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Based on 1 publication(s) in Google Scholar

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Description

Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression[1]. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K[2].

In Vivo

Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function[3]. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes[4].

Clinical Trial
Molecular Weight

484.14

Formula

C₉H₁₅N₂O₁₅P₃

CAS No.

63-39-8

SMILES

O[[email protected]]1[[email protected]](N2C(NC(C=C2)=O)=O)O[[email protected]](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[[email protected]]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 150 mg/mL (309.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0655 mL 10.3276 mL 20.6552 mL
5 mM 0.4131 mL 2.0655 mL 4.1310 mL
10 mM 0.2066 mL 1.0328 mL 2.0655 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[2]

Pancreatic duct epithelial cells are treated with (0.1 μM-1 mM) uridine triphosphate. BrdU is added after different time points (12-24 hours). Proliferation is measured using the BrdU incorporation assay in triplicate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[3]

Rats: Four main groups are tested: (1) sham without LAD ligation, (2) LAD ligation, (3) injected with UTP (0.44 µg/kg i.v.) 30 min before MI, (4) UTP injection (4.4 µg/kg i.v.) 24 h prior to MI. Several different concentrations of UTP are tested (0.044–44.4 µg/kg). Left ventricular systolic pressure (LVSP), end-diastolic pressure (LVEDP) and heart rates are monitored before, after UTP treatment and post MI[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

Uridine triphosphateUTPUridine 5'-triphosphateEndogenous MetaboliteInhibitorinhibitorinhibit

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Uridine triphosphate
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