63-39-8
63-39-8
Chemical Structure
Uridine triphosphate
Synonym(s): UTP; Uridine 5'-triphosphate
- CAS No.: 63-39-8
- Formula:C9H15N2O15P3
- Molecular Weight:484.14
IUPAC Name: ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: PGAVKCOVUIYSFO-XVFCMESISA-N
SMILES: O=C(N1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(OP(OP(O)(O)=O)(O)=O)=O)O2)NC(C=C1)=O
Biological Activity: Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors[1][2][3].
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Uridine triphosphate | Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors. | |||||||||||||||||||||
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Uridine triphosphate-13C9,15N2 sodium | Uridine triphosphate-13C9,15N2 (UTP-13C9,15N2) sodium is a labeled Uridine triphosphate sodium. Uridine triphosphate sodium can be used in nucleic acid synthesis. | |||||||||||||||||||||
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Uridine triphosphate-15N2 dilithium | 98.60% | Uridine triphosphate-15N2 (UTP-15N2 dilithium; Uridine 5'-triphosphate-15N2) dilithium is 15N labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states. | ||||||||||||||||||||
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Uridine triphosphate-d13 dilithium | 99.6% | Uridine triphosphate-d13 (UTP-d13 dilithium; Uridine 5'-triphosphate-d13) dilithium is deuterium labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states. | ||||||||||||||||||||
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Uridine triphosphate-13C9 dilithium | 99.33% | Uridine triphosphate-13C9 (UTP-13C9 dilithium; Uridine 5'-triphosphate-13C9) dilithium is 13C-labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states. | ||||||||||||||||||||
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Uridine 5'-diphosphate | Uridine-5'-diphosphate (UDP) is an important nucleotide made of uracil, ribose, and a pyrophosphate group. Uridine-5'-diphosphate is a potent, selective human P2Y6 receptor native agonist (EC50 = 300 nM; pEC50 = 6.52). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis. | |||||||||||||||||||||
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Uridine 5'-triphosphate tris salt | Uridine 5'-triphosphate tris salt is an endogenous metabolite. | |||||||||||||||||||||
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Ara-UTP | Ara-UTP is a sugar-modified nucleotide triphosphate that deceives RNA polymerases and blocks chain extension. | |||||||||||||||||||||
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Uridine-5'-O-3-thiotriphosphate | Uridine-5'-O-(3-thiotriphosphate) (UTPγS), a stable analogue of Uridine triphosphate (UTP) (HY-107372), is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability. Uridine-5'-O-(3-thiotriphosphate) stimulates inositol phosphate formation in human 1321N1 astrocytoma cells stably expressing the phospholipase C-coupled human P2U-purinoceptor (EC50 = 240 nM). | |||||||||||||||||||||
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Sp-UTP-α-S | Sp-UTP-α-S (Uridine 5-0-1-thiotrirhosphate) is a P2Y2 and P2Y4 receptor activator. Sp-UTP-α-S can be used in cancer research. | |||||||||||||||||||||
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UTPαS | UTPαS is a monomeric raw material that can be used for nucleic acid synthesis. | |||||||||||||||||||||
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UTP(αB) | UTP(αB) is a monomeric raw material that can be used for nucleic acid synthesis. | |||||||||||||||||||||
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Uridine triphosphate trisodium salt | 96.0% | Uridine triphosphate (UTP) trisodium salt is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate trisodium salt activates membrane-bound P2Y2 receptors. | ||||||||||||||||||||
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2'-OMe-uTP | 2'-OMe-uTP is a monomeric raw material that can be used for nucleic acid synthesis. | |||||||||||||||||||||
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References
- [1]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6. [Content Brief]
- [2]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998. [Content Brief]
- [3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55. [Content Brief]
