UTP trisodium salt, 100 mM Solution, PCR Grade
Based on 1 Customer Validation
UTP (Uridine 5'-triphosphate) trisodium salt, 100 mM Solution, PCR Grade is a solution prepared from uridine triphosphate at a concentration of 100 mM, free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. Uridine triphosphate (HY-107372) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors.
For research use only. We do not sell to patients.
- CAS No.: 19817-92-6
- Formula: C9H12N2Na3O15P3
- Molecular Weight:550.09
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
MoreAll DNA/RNA Synthesis Isoforms
MoreAll P2Y Receptor Isoforms
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
0.45 μM
Compound: UTP
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Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
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[PMID: 16539385] |
| HEK293 | EC50 |
0.13 μM
Compound: UTP
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Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
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[PMID: 16539385] |
| NG108-15 | EC50 |
1.26 μM
Compound: UTP
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Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
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[PMID: 19523835] |
| NG108-15 | IC50 |
1.51 μM
Compound: UTP
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Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
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[PMID: 19523835] |
UTP enhances the migration and wound repair of RT4-D6P2T cells by activating the P2Y2 receptor and increasing the activation and expression of extracellular MMP-2[2].
UTP induces MAPK phosphorylation in a biphasic manner. It causes early transient phosphorylation within 5 minutes after treatment, and late persistent phosphorylation occurs 6 hours later, lasting for up to 24 hours[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RT4-D6P2T cells
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Concentration:250 μM
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Incubation Time:5 min, 45 min, 2 h, 6 h, 12 h, 24 h, 48 h
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Result:Induces biphasic MAPK phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (250-300 g; 2-3 months) with myocardial infarction (MI)[3]
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Dosage:0.44 µg/kg 30 min before MI, and 4.4 µg/kg i.v. 24 h prior to MI.
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Administration:i.v.; once
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Result:Reduced infarct size and improves rat heart function after myocardial infarct.
Chemical Information
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CAS No. 19817-92-6
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Appearance Liquid
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Molecular Weight 550.09
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Formula C9H12N2Na3O15P3
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Color Colorless to light yellow
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SMILES
O=C(N1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)=O)O2)NC(C=C1)=O
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Synonyms
Uridine 5'-triphosphate trisodium salt, 100 mM Solution, PCR Grade
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6. [Content Brief]
[2]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998. [Content Brief]
[3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UTP trisodium salt, 100 mM Solution, PCR Grade Related Classifications
HY-107372H Related Classifications
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