UTP trisodium salt, 100 mM Solution, PCR Grade  (Synonyms: Uridine 5'-triphosphate trisodium salt, 100 mM Solution, PCR Grade)

UTP (Uridine 5'-triphosphate) trisodium salt, 100 mM Solution, PCR Grade is a solution prepared from uridine triphosphate at a concentration of 100 mM, free of DNase, RNase and phosphatase contamination, suitable for molecular biology research. Uridine triphosphate (HY-107372) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors^[1][2][3].

UTP enhances the migration and wound repair of RT4-D6P2T cells by activating the P2Y2 receptor and increasing the activation and expression of extracellular MMP-2^[2].
UTP induces MAPK phosphorylation in a biphasic manner. It causes early transient phosphorylation within 5 minutes after treatment, and late persistent phosphorylation occurs 6 hours later, lasting for up to 24 hours^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UTP (0.44-4.4 μg/kg; i.v.; once) reduces infarct size and improves rat heart function after myocardial infarct^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

550.09

C₉H₁₂N₂Na₃O₁₅P₃

19817-92-6

Liquid

Colorless to light yellow

O=C(N1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)=O)O2)NC(C=C1)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.  [Content Brief]

  [2]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.  [Content Brief]

  [3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.  [Content Brief]