4-Methylcinnamic acid
Based on 1 Customer Validation
4-Methylcinnamic acid is a cinnamic acid derivative with antifungal activity. 4-Methylcinnamic acid can overcome the tolerance of glutathione reductase mutants to 4-Methoxycinnamic acid (HY-N1387). When 4-Methylcinnamic acid is used in combination with traditional antifungal agents, it can reduce their minimum inhibitory concentrations. 4-Methylcinnamic acid can act as an intervention catalyst to enhance the efficacy of traditional antifungal agents and has application potential in targeting fungal cell wall disruption and controlling drug-resistant fungi.
For research use only. We do not sell to patients.
- Purity: 99.49%
- CAS No.: 1866-39-3
- Formula: C10H10O2
- Molecular Weight:162.19
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Infection Compound Library
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Antifungal Compound Library
HY-L048
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Traditional Chinese Medicine Active Compound Library
HY-L065
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Anti-Cancer Metabolism Compound Library
HY-L083
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Human Metabolite Library
HY-L123
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Cuproptosis Compound Library
HY-L133
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Anti-Drug-Resistant Compound Library
HY-L169
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
Biological Activity
4-Methylcinnamic acid (0.5 mM; 5-7 days) exhibits growth inhibition against Saccharomyces cerevisiae cell wall integrity mutants slt2∆ and bck1∆, and also inhibits the growth of wild-type yeast[1].
4-Methylcinnamic acid (0.5 mM; 5-7 days) completely inhibits growth in Saccharomyces cerevisiae glutathione reductase mutant glr1∆, overcoming its tolerance to 4-Methoxycinnamic acid (HY-N1387)[1].
4-Methylcinnamic acid (0.1-6.4 mM; 48 hours) reduces the minimum inhibitory concentration and exhibits a chemosensitizing effect when used in combination with Caspofungin (HY-17006A) or Octyl gallate (HY-N2011) in Aspergillus brasiliensis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1866-39-3
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Appearance Solid
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Molecular Weight 162.19
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Formula C10H10O2
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Color White to off-white
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SMILES
CC1=CC=C(C=CC(O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (616.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (15.41 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.41 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.1656 mL | 30.8280 mL | 61.6561 mL | 154.1402 mL |
| 5 mM | 1.2331 mL | 6.1656 mL | 12.3312 mL | 30.8280 mL | |
| 10 mM | 0.6166 mL | 3.0828 mL | 6.1656 mL | 15.4140 mL | |
| 15 mM | 0.4110 mL | 2.0552 mL | 4.1104 mL | 10.2760 mL | |
| 20 mM | 0.3083 mL | 1.5414 mL | 3.0828 mL | 7.7070 mL | |
| 25 mM | 0.2466 mL | 1.2331 mL | 2.4662 mL | 6.1656 mL | |
| 30 mM | 0.2055 mL | 1.0276 mL | 2.0552 mL | 5.1380 mL | |
| 40 mM | 0.1541 mL | 0.7707 mL | 1.5414 mL | 3.8535 mL | |
| 50 mM | 0.1233 mL | 0.6166 mL | 1.2331 mL | 3.0828 mL | |
| 60 mM | 0.1028 mL | 0.5138 mL | 1.0276 mL | 2.5690 mL | |
| 80 mM | 0.0771 mL | 0.3854 mL | 0.7707 mL | 1.9268 mL | |
| 100 mM | 0.0617 mL | 0.3083 mL | 0.6166 mL | 1.5414 mL |
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