Cat. No.: HY-N6599

3-Feruloylquinic acid

(Synonyms: 3-O-Feruloylquinic acid)

Customer Review

Based on 1 Customer Validation

3-Feruloylquinic acid (3-O-Feruloylquinic acid), a derivative of quinic acid-bound phenolic acid, shows antioxidant and anti-inflammatory activities.

For research use only. We do not sell to patients.

Purity: 98.49%
CAS No.: 1899-29-2
Formula: C₁₇H₂₀O₉
Molecular Weight:368.34

Storage:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

3-Feruloylquinic acid Chemical Structure

CAS No.: 1899-29-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

3-Feruloylquinic acid (3-O-Feruloylquinic acid), a derivative of quinic acid-bound phenolic acid, shows antioxidant and anti-inflammatory activities^[1]^[2].

All Interleukin Related Isoforms :

All COX Isoforms :

All NO Synthase Isoforms :

All NF-κB Isoforms :

In Vitro

3-Feruloylquinic acid scavenges ABTS radical, hydroxy radical and DPPH radical with IC₅₀s of 0.017, 0.49 and 0.06 mg/mL, respectively^[3].
3-Feruloylquinic acid (1-400 μg/mL, 24 h) inhibits LPS (HY-D1056)-induced mRNA expressions of IL-1β, IL-6, iNOS, COX-2 and NF-κB, suppresses the NO release in RAW 264.7 cell, and exhibiting antioxidant and anti-inflammatory activities^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[3]

Cell Line:

RAW 264.7
Concentration:

1-400 μg/mL
Incubation Time:

24 h
Result:

Inhibited mRNA expression of IL-1β, IL-6, iNOS, COX-2 and NF-κB.

Chemical Information

CAS No. 1899-29-2
Appearance Solid
Molecular Weight 368.34
Formula C₁₇H₂₀O₉
Color White to off-white
SMILES

COC1=C(O)C=CC(/C=C/C(O[C@H]2C[C@](O)(C[C@H](O)[C@@H]2O)C(O)=O)=O)=C1
Synonyms

3-O-Feruloylquinic acid
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Monophenols
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (271.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7149 mL

13.5744 mL

27.1488 mL

5 mM

0.5430 mL

2.7149 mL

5.4298 mL

10 mM

0.2715 mL

1.3574 mL

2.7149 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.79 mM); Suspended solution

This protocol yields a suspended solution of ≥ 2.5 mg/mL (saturation unknown). Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Holub P, et al. Induction of phenolic compounds by UV and PAR is modulated by leaf ontogeny and barley genotype. Plant Physiol Biochem. 2019;134:81-93. [Content Brief]

[2]. Alonso-Salces RM, et al. Botanical and geographical characterization of green coffee (Coffea arabica and Coffea canephora): chemometric evaluation of phenolic and methylxanthine contents. J Agric Food Chem. 2009;57(10):4224-4235. [Content Brief]

[3]. Ao X, et al., Extraction, isolation and identification of four phenolic compounds from Pleioblastus amarus shoots and their antioxidant and anti-inflammatory properties in vitro. Food Chem. 2022 Apr 16;374:131743. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7149 mL	13.5744 mL	27.1488 mL	67.8721 mL
	5 mM	0.5430 mL	2.7149 mL	5.4298 mL	13.5744 mL
	10 mM	0.2715 mL	1.3574 mL	2.7149 mL	6.7872 mL
	15 mM	0.1810 mL	0.9050 mL	1.8099 mL	4.5248 mL
	20 mM	0.1357 mL	0.6787 mL	1.3574 mL	3.3936 mL
	25 mM	0.1086 mL	0.5430 mL	1.0860 mL	2.7149 mL
	30 mM	0.0905 mL	0.4525 mL	0.9050 mL	2.2624 mL
	40 mM	0.0679 mL	0.3394 mL	0.6787 mL	1.6968 mL
	50 mM	0.0543 mL	0.2715 mL	0.5430 mL	1.3574 mL
	60 mM	0.0452 mL	0.2262 mL	0.4525 mL	1.1312 mL
	80 mM	0.0339 mL	0.1697 mL	0.3394 mL	0.8484 mL
	100 mM	0.0271 mL	0.1357 mL	0.2715 mL	0.6787 mL

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3-Feruloylquinic acid

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All Interleukin Related Isoforms

All COX Isoforms

All NO Synthase Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

3-Feruloylquinic acid Related Classifications

HY-N6599 Related Classifications