1. Metabolic Enzyme/Protease
    Immunology/Inflammation
    GPCR/G Protein
    Neuronal Signaling
  2. MAGL
    Histamine Receptor
  3. JZP-361

JZP-361 

Cat. No.: HY-121422
Handling Instructions

JZP-361 is a potent, reversible and selective inhibitor of human recombinant MAGL (hMAGL) with an IC50 of 46 nM. JZP-361 also shows antihistaminergic activities and can be used for asthma research.

For research use only. We do not sell to patients.

JZP-361 Chemical Structure

JZP-361 Chemical Structure

CAS No. : 1680193-80-9

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Description

JZP-361 is a potent, reversible and selective inhibitor of human recombinant MAGL (hMAGL) with an IC50 of 46 nM. JZP-361 also shows antihistaminergic activities and can be used for asthma research[1].

IC50 & Target

hMAGL

46 nM (IC50)

hABHD6

1.79 μM (IC50)

hFAAH

7.24 μM (IC50)

H1 Receptor

6.81 (pA2)

In Vitro

JZP-361 has almost 150-fold higher selectivity over human recombinant fatty acid amide hydrolase (hFAAH, IC50 = 7.24 μM) and 35-fold higher selectivity over human α/β-hydrolase-6 (hABHD6, IC50 = 1.79 μM)[1].
JZP-361 retains H1 antagonistic affinity (pA2 = 6.81) but did not show cannabinoid receptor activity, when tested at concentrations ≤10 μM[1].
JZP-361 displays favorable interactions within the active site of hMAGL including the important hydrogen-bonding of the carbonyl oxygen to the oxyanion hole[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

405.88

Formula

C22H20ClN5O

CAS No.
SMILES

O=C(N(CC/1)CCC1=C2C3=C(CCC4=C/2N=CC=C4)C=C(C=C3)Cl)N5N=CN=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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JZP-361
Cat. No.:
HY-121422
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