Resolvin D3 (Synonyms: RvD3)

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Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation.

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Resolvin D3 Chemical Structure

CAS No. : 916888-47-6

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25 μg (265.6 µM * 250 μL in Ethanol)	USD 880	Ask For Quote & Lead Time

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Other Forms of Resolvin D3:

Resolvin D3-d₅ Get quote

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Description

Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation^[1]^[2].

In Vitro

RvD3 (RvD3; 10 nM) significantly inhibits tumor necrosis factor-α–induced NF-κB activation in A549 epithelial cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Resolvin D3 (RvD3; 100 ng/100 µl; IP; daily for 6 days) alleviates arthritis progression, reduces edema and limits leukocyte numbers in murine K/BxN-serum induced arthritis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57Bl/6 mice (12 weeks old) or ALX/fpr2/3 KO mice^[1]
Dosage:	100 ng/100 µl
Administration:	IP; daily for 6 days
Result:	Alleviated arthritis progression, reduced edema and limited leukocyte numbers in murine K/BxN-serum induced arthritis.

Molecular Weight

376.49

Formula

C₂₂H₃₂O₅

CAS No.

916888-47-6

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC/C=C\C[C@H](O)/C=C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: ≥95.0%

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Data Sheet (264 KB) SDS (251 KB)

COA (239 KB)

Handling Instructions (2659 KB)

References

[1]. Hildur H Arnardottir, et al. Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. J Immunol. 2016 Sep 15;197(6):2362-8. [Content Brief]

[2]. Jennifer K Colby, et al. Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. Am J Pathol. 2016 Jul;186(7):1801-1813. [Content Brief]

Resolvin D3 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resolvin D3916888-47-6RvD3Resolvin D 3Resolvin D-3RvD 3RvD-3OthersdocosahexaenoicacidDHAarthritisinflammationNF-κBA549epithelialInhibitorinhibitorinhibit

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