Glycyl-L-histidyl-L-lysine

Name: Glycyl-L-histidyl-L-lysine
Brand: MedChemExpress
SKU: HY-P0046
Rating: 4.5 (2 reviews)

Cat. No.: HY-P0046 Purity: 99.60%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Glycyl-L-histidyl-L-lysine Chemical Structure

CAS No. : 49557-75-7

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Free Sample (0.1 - 0.5 mg)		Apply Now
1 g	USD 40	In-stock	Estimated Time of Arrival: December 31
5 g	USD 120	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE Glycyl-L-histidyl-L-lysine

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Glycyl-L-histidyl-L-lysine and its copper complexes and saccharomyces/copper ferment on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line^[1].
Glycyl-L-histidyl-L-lysine and its copper complexes decreases TNF-α-dependent IL-6 secretion in fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 1.5, 5, 50, 150, and 450 mg/kg; 10 times ) can stimulate mitotic activity of hepatocytes and dose-dependently suppresse immune reactivity^[2].
Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 0.5, 5, and 50 μg/kg) can produce an anxiolytic effect in the elevated plus maze test^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

340.38

Formula

C₁₄H₂₄N₆O₄

CAS No.

49557-75-7

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (293.79 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9379 mL	14.6895 mL	29.3789 mL
5 mM	0.5876 mL	2.9379 mL	5.8758 mL
10 mM	0.2938 mL	1.4689 mL	2.9379 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.60%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (250 KB) HNMR (101 KB) RP-HPLC (125 KB)

Handling Instructions (2659 KB)

References

[1]. Arkadiusz Gruchlik, et al. Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. Acta Pol Pharm. 2012 Nov-Dec;69(6):1303-6. [Content Brief]

[2]. M Yu Smakhtin, et al. Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor. Bull Exp Biol Med. 2002 Jun;133(6):586-7. [Content Brief]

[3]. I Bobyntsev, et al. Anxiolytic effects of Gly-His-Lys peptide and its analogs. Bull Exp Biol Med. 2015 Apr;158(6):726-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.9379 mL	14.6895 mL	29.3789 mL	73.4473 mL
	5 mM	0.5876 mL	2.9379 mL	5.8758 mL	14.6895 mL
	10 mM	0.2938 mL	1.4689 mL	2.9379 mL	7.3447 mL
	15 mM	0.1959 mL	0.9793 mL	1.9586 mL	4.8965 mL
	20 mM	0.1469 mL	0.7345 mL	1.4689 mL	3.6724 mL
	25 mM	0.1175 mL	0.5876 mL	1.1752 mL	2.9379 mL
	30 mM	0.0979 mL	0.4896 mL	0.9793 mL	2.4482 mL
	40 mM	0.0734 mL	0.3672 mL	0.7345 mL	1.8362 mL
	50 mM	0.0588 mL	0.2938 mL	0.5876 mL	1.4689 mL
	60 mM	0.0490 mL	0.2448 mL	0.4896 mL	1.2241 mL
	80 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.9181 mL
	100 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7345 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycyl-L-histidyl-L-lysine49557-75-7Othershepatotropic immunosuppressoranxiolytic effectskin toleranceInhibitorinhibitorinhibit

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Glycyl-L-histidyl-L-lysine

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