Acetyl tetrapeptide-2
Based on 1 Customer Validation
Acetyl tetrapeptide-2 is a bio-active peptide that exhibits anti-aging activity. Acetyl tetrapeptide-2 can reduce loss of thymic factors. Acetyl tetrapeptide-2 can increase the stiffness of HaCaT cells. Acetyl tetrapeptide-2 is a stimulator of structural skin elements including collagen and elastin.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 757942-88-4
- Formula: C26H39N5O9
- Molecular Weight:565.62
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Acetyl tetrapeptide-2 (Compound P1) (0.5-50 μg/mL, 48 h) results in increased stiffness of HaCaT cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT cells
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Concentration:0.5, 5, 50 μg/mL
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Incubation Time:48 h
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Result:Contributed to cellular cohesion due to Focal Adhesions (FAs), interface between the actin cytoskeleton and extracellular matrix by overexpression genes involved in these processes.
Resulted in increased production of elastin, and collagen type I.
Showed similar high density of actin filaments in the whole cytoplasm area, even in peripheral parts.
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Cell Line:HaCaT cells
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Concentration:0.5, 5, 50 μg/mL
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Incubation Time:48 h
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Result:Significantly decreased the relative mRNA expression of ACTN1, ITGB4, and COL17A1 with 50 μg/mL, whilst significantly upregulated COL17A1 with 0.5 μg/mL.
Chemical Information
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CAS No. 757942-88-4
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Appearance Solid
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Molecular Weight 565.62
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Formula C26H39N5O9
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Color White to off-white
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Sequence
Ac-Lys-Asp-Val-Tyr
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Sequence Shortening
Ac-KDVY
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (176.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhang L, et al. Cosmeceuticals and peptides. Clin Dermatol. 2009;27(5):485-494. [Content Brief]
[2]. He, Q., et al., (2025). Bioactive oligopeptides and the application in skin regeneration and rejuvenation. Journal of applied biomaterials & functional materials, 23, 22808000251330974. [Content Brief]
[3]. Kobiela, T., et al., (2018). The Effect of Anti-aging Peptides on Mechanical and Biological Properties of HaCaT Keratinocytes. International journal of peptide research and therapeutics, 24(4), 577–587. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7680 mL | 8.8399 mL | 17.6797 mL | 44.1993 mL |
| 5 mM | 0.3536 mL | 1.7680 mL | 3.5359 mL | 8.8399 mL | |
| 10 mM | 0.1768 mL | 0.8840 mL | 1.7680 mL | 4.4199 mL | |
| 15 mM | 0.1179 mL | 0.5893 mL | 1.1786 mL | 2.9466 mL | |
| 20 mM | 0.0884 mL | 0.4420 mL | 0.8840 mL | 2.2100 mL | |
| 25 mM | 0.0707 mL | 0.3536 mL | 0.7072 mL | 1.7680 mL | |
| 30 mM | 0.0589 mL | 0.2947 mL | 0.5893 mL | 1.4733 mL | |
| 40 mM | 0.0442 mL | 0.2210 mL | 0.4420 mL | 1.1050 mL | |
| 50 mM | 0.0354 mL | 0.1768 mL | 0.3536 mL | 0.8840 mL | |
| 60 mM | 0.0295 mL | 0.1473 mL | 0.2947 mL | 0.7367 mL | |
| 80 mM | 0.0221 mL | 0.1105 mL | 0.2210 mL | 0.5525 mL | |
| 100 mM | 0.0177 mL | 0.0884 mL | 0.1768 mL | 0.4420 mL |
Acetyl tetrapeptide-2 Related Classifications
HY-P2663 Related Classifications
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