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OATD-01 

Cat. No.: HY-137464A
Handling Instructions

OATD-01 is a highly potent, first-in-class, orally active and selective chitinase inhibitor with low nanomolar activity toward CHIT1 (hCHIT1,IC50=23 nM). OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets. OATD-01 exhibits significant antifibrotic efficacy in vivo and can be used for pulmonary fibrosis (IPF) research.

For research use only. We do not sell to patients.

OATD-01 Chemical Structure

OATD-01 Chemical Structure

CAS No. : 2088453-21-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
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10 mg USD 250 In-stock
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25 mg USD 450 In-stock
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50 mg USD 750 In-stock
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100 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

OATD-01 is a highly potent, first-in-class, orally active and selective chitinase inhibitor with low nanomolar activity toward CHIT1 (hCHIT1,IC50=23 nM). OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets. OATD-01 exhibits significant antifibrotic efficacy in vivo and can be used for pulmonary fibrosis (IPF) research[1].

In Vitro

OATD-01 exhibits high affinity toward h/mCHIT1 and h/mAMCase, and the inhibitory constants (Ki) for all four enzymes are 17.3 nM, 26.05 nM, 4.8 nM and 5.7 nM, respectively[1]. These Ki values reveals good correlation with earlier established IC50 data, the IC50 values are 23 nM, 28 nM, 9 nM and 7.8 nM for hCHIT1,mCHIT1, hAMCase and mAMCase, respectively.[1].
Off-target in vitro effects of compound OATD-01 have been evaluated at 10 μM in the Eurofins Panlabs panel of 98 in vitro binding and enzymatic assays, involving diverse molecular classes of proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

OATD-01 (oral gavage; 30 mg/kg, 100 mg/kg; once daily; 21 days) shows significant antifibrotic efficacy in an animal model of bleomycin-induced pulmonary fibrosis. It reduces the degree of lung fibrosis in a dose-dependent manner, ultimately achieving comparable therapeutic efficacy to reference treatment with Nintedanib in this animal model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice[1]
Dosage: 30 mg/kg, 100 mg/kg
Administration: Oral gavage; 30 mg/kg, 100 mg/kg; once daily; 21 days
Result: Reduced the degree of lung fibrosis in vivo[1]
Molecular Weight

390.91

Formula

C₁₉H₂₇ClN₆O

CAS No.
SMILES

NC1=NNC(N2CCC(N3C[[email protected]](C)OC[[email protected]@H]3CC4=CC=C(Cl)C=C4)CC2)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (255.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5581 mL 12.7907 mL 25.5813 mL
5 mM 0.5116 mL 2.5581 mL 5.1163 mL
10 mM 0.2558 mL 1.2791 mL 2.5581 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

OATD-01OATD01OATD 01OthersCHIT1chitinaseantifibroticpulmonary fibrosisIPFInhibitorinhibitorinhibit

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