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Exendin-4

(Synonyms: Exenatide)
72 Cited Publications
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Based on 72 publication(s) in Google Scholar

Exendin‑4 (Exenatide) is an orally active, blood-brain barrier-permeable glucagon-like peptide-1 receptor (GLP‑1 receptor) agonist that resists degradation mediated by dipeptidyl peptidase IV. Exendin‑4 mediates multiple glucose-regulating effects, including stimulation of glucose-dependent insulin secretion, inhibition of glucagon production, increase in β-cell mass, delay of gastric emptying, reduction of food intake, improvement of peripheral insulin sensitivity, and restoration of normal islet structure. Exendin‑4 inhibits oxidative stress, alleviates inflammatory responses, and reduces neuronal apoptosis. Exendin‑4 reduces the aggregation level of mutant huntingtin, improves motor function, prolongs survival time, and regulates the expression levels of leptin and ghrelin. Exendin‑4 can be used in research related to type 2 diabetes, acute ischemic stroke, and Huntington's disease.

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  • Reinheit: 99.89%
  • CAS. Nr.: 141758-74-9
  • Formel: C184H282N50O60S
  • Molecular Weight:4186.57
  • Speicherung:

    Sealed storage, away from moisture and light, under nitrogen.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light, under nitrogen)

  • Exendin-4 Chemical Structure
    Exendin-4 Chemical Structure
  • Experimental Validation Results for Exendin-4
  • Experimental Validation Results for Exendin-4
  • Experimental Validation Results for Exendin-4
  • Experimental Validation Results for Exendin-4
  • Experimental Validation Results for Exendin-4
CAS. Nr.: 141758-74-9
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RT-PCRPK/PD AnalysisIn Vivo ImagingCell Proliferation/Viability Assay
  • PK/PD Analysis
  • In Vivo Imaging
  • RT-PCR
  • Cell Proliferation/Viability Assay
  • RT-PCR

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  • Exendin-4 Chemical Structure
    Exendin-4 Chemical Structure
    1/16
  • 1/16

    Exendin-4 purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2025 Nov 25:57:646-659. [Abstract]

    Customer Validation
     Pharmacokinetics of Exendin-4 following oral versus subcutaneous administration in mice. (a) Experimental design: Fasted mice received either (i) oral PBS + exendin-4 capsule (1 mg/kg), (ii) oral nanofibrils (20 mg/mL, 200 µL) + exendin-4 capsule (1 mg/kg), or (iii) subcutaneous exendin-4 (0.1 mg/kg, pharmacological control). (b) Serum exendin-4 levels over 6 hours. (c) Corresponding AUC analysis (0-6 h).

  • 1/16

    Exendin-4 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Mar 10:S2090-1232(25)00174-2. [Abstract]

    Customer Validation
     Micro-CT images representing trabecular formation in control mice, mice with T2DM, mice with T2DM treated with Exendin-4 (20 mg/kg)/Metformin, and GLP-1R knockout mice with T2DM treated with Exendin-4 within a region of interest (ROI). n=6 mice per group. Con: control; T2DM: type 2 diabetes mellitus; Met: metformin; Ex-4: Exendin-4; Micro-CT: micro-computed tomography.

  • 1/16

    Exendin-4 purchased from MedChemExpress. Usage Cited in: Gut. 2023 Feb;72(2):314-324. [Abstract]

    Customer Validation
     Exendin-4 (2 nmol/kg/day) supplementation improves the metabolic defect of TGR5 KO fed western-style diet (WSD) enriched with oligofructose (OFS).

  • 1/16

    Exendin-4 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2019 Oct 25:10:1230. [Abstract]

    Customer Validation
     Exendin-4 or FSK treatment reduces ER stress-induced β-cell viability. INS-1 cells are incubated with THAP (0.5 μM), with Eexendin-4.

  • 1/16

    Exendin-4 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2019 Oct 25:10:1230. [Abstract]

    Customer Validation
     INS-1 cells are incubated with THAP (0.5 μM), H89, with Exendin-4 or FSK at indicated concentration for 24 h, then the IL-1β level is analyzed by qRT-PCR (n = 3).

  • Exendin-4