1. Neuronal Signaling
    NF-κB
    Protein Tyrosine Kinase/RTK
  2. Monoamine Oxidase
    Keap1-Nrf2
    ROS
  3. Nrf2-ARE/hMAO-B/QR2 modulator 1

Nrf2-ARE/hMAO-B/QR2 modulator 1 

Cat. No.: HY-144635
Handling Instructions

Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC50s of 8.05, 9.83 and 0.57 μM for hMAO-B, NRF2 and QR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated mice hippocampal slices.

For research use only. We do not sell to patients.

Nrf2-ARE/hMAO-B/QR2 modulator 1 Chemical Structure

Nrf2-ARE/hMAO-B/QR2 modulator 1 Chemical Structure

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Description

Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC50s of 8.05, 9.83 and 0.57 μM for hMAO-B, NRF2 and QR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated mice hippocampal slices[1].

IC50 & Target

IC50: 8.05 μM (hMAO-B), 9.83 μM (NRF2), 0.57 μM (QR2)[1]

In Vitro

Nrf2-ARE/hMAO-B/QR2 modulator 1 (compound 4e) (100 μM; 24 hours) reduces the viability of SH-SY5Y cells by around 30%[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 24 hours for pre-treatment, then coincubated for another 24 hours with 10 nM okadaic acid (OA)) significantly increases the cell viability of OA-treated rat primary cortical neurons to 70-80%[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (10 μM) shows the highest expression of young cells (TuJ-1) and mature neurons (MAP-2), as well as the greatest distance of cell migration in mice NSCs which isolated from SGZ[1].
Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 72 hours) confers neuroprotection and reduces cell death, decreasing ROS production in mice hippocampal slices exposed to OA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

256.26

Formula

C14H12N2O3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Nrf2-ARE/hMAO-B/QR2 modulator 1
Cat. No.:
HY-144635
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