Fmoc-His(Trt)-OH
Based on 1 publication(s) in Google Scholar
Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 109425-51-6
- Formula: C40H33N3O4
- Molecular Weight:619.71
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fmoc-His(Trt)-OH
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Biological Activity
Fmoc-His(Trt)-OH is primarily used as a standard building block in solid-phase peptide synthesis (SPPS) for the introduction of histidine residues. Its Fmoc group protects the α-amino group, and the Trt group protects the imidazole ring of the histidine side chain, reducing racemization and byproduct formation during synthesis. Fmoc-His(Trt)-OH can spontaneously self-assemble under conditions of pH < 4 to form a nanofiber network, constructing a hydrogel scaffold with a water content exceeding 99% (w/w). The fibers have a diameter of approximately 22 nm, matching the size of extracellular matrix (ECM) components[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 109425-51-6
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Appearance Solid
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Molecular Weight 619.71
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Formula C40H33N3O4
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (161.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.6137 mL | 8.0683 mL | 16.1366 mL | 40.3414 mL |
| 5 mM | 0.3227 mL | 1.6137 mL | 3.2273 mL | 8.0683 mL | |
| 10 mM | 0.1614 mL | 0.8068 mL | 1.6137 mL | 4.0341 mL | |
| 15 mM | 0.1076 mL | 0.5379 mL | 1.0758 mL | 2.6894 mL | |
| 20 mM | 0.0807 mL | 0.4034 mL | 0.8068 mL | 2.0171 mL | |
| 25 mM | 0.0645 mL | 0.3227 mL | 0.6455 mL | 1.6137 mL | |
| 30 mM | 0.0538 mL | 0.2689 mL | 0.5379 mL | 1.3447 mL | |
| 40 mM | 0.0403 mL | 0.2017 mL | 0.4034 mL | 1.0085 mL | |
| 50 mM | 0.0323 mL | 0.1614 mL | 0.3227 mL | 0.8068 mL | |
| 60 mM | 0.0269 mL | 0.1345 mL | 0.2689 mL | 0.6724 mL | |
| 80 mM | 0.0202 mL | 0.1009 mL | 0.2017 mL | 0.5043 mL | |
| 100 mM | 0.0161 mL | 0.0807 mL | 0.1614 mL | 0.4034 mL |
Fmoc-His(Trt)-OH Related Classifications
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