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  3. Amino Acid Derivatives
  4. Fmoc-His(Trt)-OH

Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration.

For research use only. We do not sell to patients.

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Fmoc-His(Trt)-OH

Fmoc-His(Trt)-OH Chemical Structure

CAS No. : 109425-51-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Other Forms of Fmoc-His(Trt)-OH:

Fmoc-His(Trt)-OH Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Fmoc-His(Trt)-OH

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  • Purity & Documentation

  • References

  • Customer Review

Description

Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration[1].

In Vitro

Fmoc-His(Trt)-OH is primarily used as a standard building block in solid-phase peptide synthesis (SPPS) for the introduction of histidine residues. Its Fmoc group protects the α-amino group, and the Trt group protects the imidazole ring of the histidine side chain, reducing racemization and byproduct formation during synthesis. Fmoc-His(Trt)-OH can spontaneously self-assemble under conditions of pH < 4 to form a nanofiber network, constructing a hydrogel scaffold with a water content exceeding 99% (w/w). The fibers have a diameter of approximately 22 nm, matching the size of extracellular matrix (ECM) components[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-His(Trt)-OH Related Antibodies
Molecular Weight

619.71

Formula

C40H33N3O4
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (161.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6137 mL 8.0683 mL 16.1366 mL
5 mM 0.3227 mL 1.6137 mL 3.2273 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.88%

SDS (394 KB)

COA (256 KB) HNMR (135 KB) RP-HPLC (227 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6137 mL 8.0683 mL 16.1366 mL 40.3414 mL
5 mM 0.3227 mL 1.6137 mL 3.2273 mL 8.0683 mL
10 mM 0.1614 mL 0.8068 mL 1.6137 mL 4.0341 mL
15 mM 0.1076 mL 0.5379 mL 1.0758 mL 2.6894 mL
20 mM 0.0807 mL 0.4034 mL 0.8068 mL 2.0171 mL
25 mM 0.0645 mL 0.3227 mL 0.6455 mL 1.6137 mL
30 mM 0.0538 mL 0.2689 mL 0.5379 mL 1.3447 mL
40 mM 0.0403 mL 0.2017 mL 0.4034 mL 1.0085 mL
50 mM 0.0323 mL 0.1614 mL 0.3227 mL 0.8068 mL
60 mM 0.0269 mL 0.1345 mL 0.2689 mL 0.6724 mL
80 mM 0.0202 mL 0.1009 mL 0.2017 mL 0.5043 mL
100 mM 0.0161 mL 0.0807 mL 0.1614 mL 0.4034 mL
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Fmoc-His(Trt)-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-His(Trt)-OH109425-51-6Amino Acid DerivativesTrtside-chainHisFmoc-αNH2peptidesracemizationInhibitorinhibitorinhibit

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