1. Others
  2. Amino Acid Derivatives
  3. Fmoc-His(Trt)-OH

Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation.

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Fmoc-His(Trt)-OH Chemical Structure

Fmoc-His(Trt)-OH Chemical Structure

CAS No. : 109425-51-6

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Based on 1 publication(s) in Google Scholar

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Description

Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1].

Molecular Weight

619.71

Formula

C40H33N3O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H](NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)CC4=CN(C=N4)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (161.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6137 mL 8.0683 mL 16.1366 mL
5 mM 0.3227 mL 1.6137 mL 3.2273 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.88%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6137 mL 8.0683 mL 16.1366 mL 40.3414 mL
5 mM 0.3227 mL 1.6137 mL 3.2273 mL 8.0683 mL
10 mM 0.1614 mL 0.8068 mL 1.6137 mL 4.0341 mL
15 mM 0.1076 mL 0.5379 mL 1.0758 mL 2.6894 mL
20 mM 0.0807 mL 0.4034 mL 0.8068 mL 2.0171 mL
25 mM 0.0645 mL 0.3227 mL 0.6455 mL 1.6137 mL
30 mM 0.0538 mL 0.2689 mL 0.5379 mL 1.3447 mL
40 mM 0.0403 mL 0.2017 mL 0.4034 mL 1.0085 mL
50 mM 0.0323 mL 0.1614 mL 0.3227 mL 0.8068 mL
60 mM 0.0269 mL 0.1345 mL 0.2689 mL 0.6724 mL
80 mM 0.0202 mL 0.1009 mL 0.2017 mL 0.5043 mL
100 mM 0.0161 mL 0.0807 mL 0.1614 mL 0.4034 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Fmoc-His(Trt)-OH
Cat. No.:
HY-W010712
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