1. Membrane Transporter/Ion Channel
  2. Proton Pump
  3. Lansoprazole

Lansoprazole (Synonyms: AG-1749)

Cat. No.: HY-13662 Purity: >98.0%
Handling Instructions

Lansoprazole(AG 1749) is a proton pump inhibitor which prevents the stomach from producing acid.

For research use only. We do not sell to patients.

Lansoprazole Chemical Structure

Lansoprazole Chemical Structure

CAS No. : 103577-45-3

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10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
1 g USD 72 In-stock
Estimated Time of Arrival: December 31
5 g USD 312 In-stock
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Description

Lansoprazole(AG 1749) is a proton pump inhibitor which prevents the stomach from producing acid. Target: Proton Pump Lansoprazole, a substituted benzimidizole proton pump inhibitor, on pharmacokinetics and metabolism of theophylline has been studied in healthy adults given oral lansoprazole 30 mg once daily for 11 days. On Days 4 and 11 of 300 mg aminophylline was simultaneously administered orally and blood samples for theophylline analysis were taken over 24 h [1]. Patients in the lansoprazole group were significantly less likely to have a recurrence of ulcer complications than patients in the placebo group (P=0.008). There was no significant difference in mortality between the two groups [2]. lansoprazole (AG-1749) and omeprazole, were found to have significant activities against this organism. The activity of lansoprazole was comparable to that of bismuth citrate, with MICs ranging from 3.13 to 12.5 micrograms/ml, and fourfold more potent than that of omeprazole [3]. Clinical indications: Duodenal ulcer; Esophagitis; Gastroesophageal reflux; Gastrointestinal disease; Helicobacter pylori infection; Peptic ulcer; Stomach ulcer; Ulcer; Zollinger-Ellison syndrome FDA Approved Date: May 10, 1995 Toxicity: Symptoms of overdose include abdominal pain, nausea and diarrhea.

Clinical Trial
Molecular Weight

369.36

Formula

C₁₆H₁₄F₃N₃O₂S

CAS No.

103577-45-3

SMILES

O=S(C1=NC2=CC=CC=C2N1)CC3=NC=CC(OCC(F)(F)F)=C3C

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Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (270.74 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7074 mL 13.5369 mL 27.0739 mL
5 mM 0.5415 mL 2.7074 mL 5.4148 mL
10 mM 0.2707 mL 1.3537 mL 2.7074 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
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Lansoprazole
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