(S)-Lansoprazole
Based on 1 Customer Validation
(S)-Lansoprazole (Levolansoprazole) is an isoform of Lansoprazole (HY-13662), which is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
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- Pureté : 98.90%
- CAS No.: 138530-95-7
- Formule: C16H14F3N3O2S
- Masse moléculaire:369.36
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Stockage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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HY-13662
LansoprazoleProton Pump Inhibitor -
HY-W013186
Lansoprazole sulfideAnti-tuberculous Agent -
HY-17421
TenatoprazoleProton Pump Inhibitor -
HY-G0007
Omeprazole sulfoneUlcer Healing Supporter -
HY-15295
Vonoprazan FumaratePotassium-Competitive Acid Blocker -
HY-17507A
Pantoprazole sodiumProton Pump Inhibitor -
HY-15295R
Vonoprazan Fumarate (Standard)Potassium-Competitive Acid Blocker -
HY-B0656A
Rabeprazole sodiumPump Inhibitor -
HY-17022
Esomeprazole magnesium trihydrateH+, K+-ATPase Inhibitor -
HY-13662R
Lansoprazole (Standard)Proton Pump Inhibitor -
HY-17507AR
Pantoprazole sodium (Standard)Proton Pump Inhibitor -
HY-128000
ML095PLAP Inhibitor
Voir tous les produits spécifiques à Isoform Phospholipase
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Activité biologique
Description
In Vitro
Lansoprazole from 0.3 to 3 μM inhibits gastric acid formation in a concentration-dependent manner (IC50 of 0.76 μM)[4].
Lansoprazole (30-300 μM) both induced concentration-dependent, reversible and reproducible relaxations of arteries[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Lansoprazole (20 mg/kg and 40 mg/kg, p.o.) significantly reduces the STZ and HFD- induced increase in AChE activity[3].
Lansoprazole (20 mg/kg and 40 mg/kg, p.o.) significantly reduces the STZ and HFD- induced rise in brain MPO level[3].
Further HFD mice treated with lansoprazole (20 mg/kg and 40 mg/kg, p.o.) shows a marked decrease in the body weight in comparison to the control animals[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 138530-95-7
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Appearance Solid
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Masse moléculaire 369.36
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Formule C16H14F3N3O2S
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Color Off-white to light yellow
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SMILES
O=[S@@](CC1=NC=CC(OCC(F)(F)F)=C1C)C2=NC3=CC=CC=C3N2
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Synonyms
Levolansoprazole
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (338.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Kokufu, T., et al., Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. Eur J Clin Pharmacol, 1995. 48(5): p. 391-5. [Content Brief]
[2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. [Content Brief]
[3]. Rupinder K Sodhi, et al. Defensive effect of lansoprazole in dementia of AD type in mice exposed to streptozotocin and cholesterol enriched diet. PLoS One. 2013 Jul 31;8(7):e70487. [Content Brief]
[4]. Jun Matsukawa, et al. A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands. Biochem Pharmacol. 2011 May 1;81(9):1145-51. [Content Brief]
[5]. Erdinc Naseri, et al. Proton pump inhibitors omeprazole and lansoprazole induce relaxation of isolated human arteries. Eur J Pharmacol. 2006 Feb 15;531(1-3):226-31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7074 mL | 13.5369 mL | 27.0739 mL | 67.6846 mL |
| 5 mM | 0.5415 mL | 2.7074 mL | 5.4148 mL | 13.5369 mL | |
| 10 mM | 0.2707 mL | 1.3537 mL | 2.7074 mL | 6.7685 mL | |
| 15 mM | 0.1805 mL | 0.9025 mL | 1.8049 mL | 4.5123 mL | |
| 20 mM | 0.1354 mL | 0.6768 mL | 1.3537 mL | 3.3842 mL | |
| 25 mM | 0.1083 mL | 0.5415 mL | 1.0830 mL | 2.7074 mL | |
| 30 mM | 0.0902 mL | 0.4512 mL | 0.9025 mL | 2.2562 mL | |
| 40 mM | 0.0677 mL | 0.3384 mL | 0.6768 mL | 1.6921 mL | |
| 50 mM | 0.0541 mL | 0.2707 mL | 0.5415 mL | 1.3537 mL | |
| 60 mM | 0.0451 mL | 0.2256 mL | 0.4512 mL | 1.1281 mL | |
| 80 mM | 0.0338 mL | 0.1692 mL | 0.3384 mL | 0.8461 mL | |
| 100 mM | 0.0271 mL | 0.1354 mL | 0.2707 mL | 0.6768 mL |
(S)-Lansoprazole Related Classifications
HY-13662C Related Classifications
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