1. Anti-infection
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. Bacterial
    STAT
  3. Golotimod

Golotimod (Synonyms: SCV 07; Gamma-D-glutamyl-L-tryptophan)

Cat. No.: HY-14743
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Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2).

For research use only. We do not sell to patients.

Golotimod Chemical Structure

Golotimod Chemical Structure

CAS No. : 229305-39-9

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Description

Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2)[1][2][3].

IC50 & Target[2]

STAT3

 

In Vivo

Golotimod (SCV-07) (oral gavage or subcutaneous injection, 100 μg/kg, 5 days) reduces experimental recurrent genital HSV-2 disease by oral administration, more importantly, oral SCV07 after fasting shows a greater reduction in incidence and severity than SCV-07 without fasting in female hartley guinea pigs[1].
Golotimod (SCV-07) (subcutaneous injection, once or twice a day from days 1 to 20, 100 μg/kg) can reduce the severity and duration of acute and split radiation-induced oral mucositis (OM) and short the duration of ulcerative OM in male LVG golden Syrian Hamsters[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Hartley guinea pigs (250-300 g) infected HSV-2[1]
Dosage: 100 μg/kg
Administration: Oral gavage or subcutaneous injection; 5 days
Result: Reduced incidence of lesions from 55% (one week before treatment) to only 18% by oral administration, and showed no significant reduction in disease by subcutaneous injection of SCV-07.
Animal Model: Male LVG golden Syrian Hamsters weighing approximately 80 g with radiation-induced mucositis[3]
Dosage: 10, 100 μg/kg or 1 mg/kg
Administration: Subcutaneous injection; once or twice a day from days 1 to 20
Result: Showed a peak mucositis of 3.0 on day 18 in the control group compared to only 2.2 in the test group, and the mucositis score in the SCV-07 treated hamsters was only 6.3% compared to 28.1% in the control group at dose of 100 μg/kg.
Significantly decreased the severity and duration of oral mucositis (OM) at dose of 10 μg/kg, 100 μg/kg or 1 mg/kg.
Clinical Trial
Molecular Weight

333.34

Formula

C16H19N3O5

CAS No.
SMILES

O=C(CC[[email protected]@](N)(C(O)=O)[H])N[[email protected]]([H])(C(O)=O)CC1=CNC2=C1C=CC=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Golotimod
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