1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Eicosapentaenoic acid ethyl ester

Eicosapentaenoic acid ethyl ester  (Synonyms: EPA ethyl ester; Ethyl eicosapentaenoate; AMR101)

Cat. No.: HY-B0747 Purity: ≥98.0%
COA Handling Instructions

Eicosapentaenoic acid ethyl ester (EPA ethyl ester) is an orally active ω-3 fatty acid agent. Eicosapentaenoic acid ethyl ester could improve the activity of liver β-oxidase in vitro, reduce the level of liver total triglyceride, increase the content of liver triglyceride and phospholipid ω-3 fatty acid, and increase the total ω-3 fatty acid level in rats.

For research use only. We do not sell to patients.

Eicosapentaenoic acid ethyl ester Chemical Structure

Eicosapentaenoic acid ethyl ester Chemical Structure

CAS No. : 86227-47-6

Size Price Stock Quantity
Liquid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 79 In-stock
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Liquid
50 mg USD 72 In-stock
100 mg USD 120 In-stock
500 mg USD 420 In-stock
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5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Eicosapentaenoic acid ethyl ester:

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Description

Eicosapentaenoic acid ethyl ester (EPA ethyl ester) is an orally active ω-3 fatty acid agent. Eicosapentaenoic acid ethyl ester could improve the activity of liver β-oxidase in vitro, reduce the level of liver total triglyceride, increase the content of liver triglyceride and phospholipid ω-3 fatty acid, and increase the total ω-3 fatty acid level in rats[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Eicosapentaenoic acid ethyl ester (300 mg/kg, oral, For 4 weeks) can inhibit the decrease of thyroid hormone levels and the change of thyroid follicles induced by 1-methyl-2-imidazole thiol (MMI) in hypothyroidism rats[2].
Eicosapentaenoic acid ethyl ester (1 g/kg, gavage for 5 weeks) reverses the increase in plasma cholesterol level and decreased circulating triglyceride level in rats with high-fat diet[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MMI-Induced hypothyroid rats[2]
Dosage: 300 mg/kg
Administration: p.o. for 4 weeks
Result: Elevated the levels of EPA, T3 and T4
Animal Model: Lean and overweight (high-fat-fed) rats[3]
Dosage: 1 g/kg
Administration: i.g. for 5 weeks
Result: Decreased the levels of cholesterol and TG.
Clinical Trial
Molecular Weight

330.50

Formula

C22H34O2

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(OCC)=O

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (302.57 mM; Need ultrasonic)

Ethanol : 50 mg/mL (151.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0257 mL 15.1286 mL 30.2572 mL
5 mM 0.6051 mL 3.0257 mL 6.0514 mL
10 mM 0.3026 mL 1.5129 mL 3.0257 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (15.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

    Solubility: 5 mg/mL (15.13 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 5 mg/mL (15.13 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (7.56 mM); Suspended solution; Need ultrasonic

  • 5.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (7.56 mM); Suspended solution; Need ultrasonic

  • 6.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.56 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Eicosapentaenoic acid ethyl ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Eicosapentaenoic acid ethyl ester
Cat. No.:
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