2. Disease Areas
  3. Metabolic or Endocrine Disease
  4. Thyroid Disease
  5. Hypothyroidism

Hypothyroidism

Hypothyroidism is a common endocrine disorder characterized by insufficient production of thyroid hormones, leading to symptoms such as fatigue, cold intolerance, weight gain, constipation, depression, muscle aches, slow heart rate, and cognitive impairment. It may result from autoimmune destruction (e.g., Hashimoto’s thyroiditis), surgical removal or radiation damage to the thyroid gland, or certain medications. Untreated hypothyroidism during pregnancy can impair fetal neurodevelopment. The condition can also contribute to sleep disturbances and worsen obstructive sleep apnea. Diagnosis involves clinical evaluation and blood tests measuring TSH and thyroid hormone levels. Treatment typically includes lifelong levothyroxine replacement therapy, with management tailored to individual symptoms and severity.

Hypothyroidism (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-114557
    NSC 90469 1041-01-6 99.41%
    NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity.
    NSC 90469
  • HY-125946
    Latanoprost lactone diol 145667-75-0 99.86%
    Latanoprost lactone diol is a small organic molecule derived from Prostaglandin F2α (HY-12956), serving as a key synthetic intermediate and inactive metabolism-related form of Latanoprost (HY-B0577). Latanoprost lactone diol is significantly upregulated in hypothyroid rats, and its level can be reversed by crude polysaccharide, lactone and oligosaccharide fractions from the rhizome of Atractylodis macrocephalae. Latanoprost lactone diol can be used in studies related to hypothyroidism.
    Latanoprost lactone diol
  • HY-179356
    Octadecyl β-D-glucopyranosiduronic acid 1413439-62-9
    Octadecyl β-D-glucopyranosiduronic acid (Compound 9) is a parathyroid hormone 1 receptor (PTH1R) activator, with a pEC50 value > 9. Octadecyl β-D-glucopyranosiduronic acid can be used for research on hypoparathyroidism.
    Octadecyl β-D-glucopyranosiduronic acid