Latanoprost lactone diol
Based on 1 Customer Validation
Latanoprost lactone diol is a small organic molecule derived from Prostaglandin F2α (HY-12956), serving as a key synthetic intermediate and inactive metabolism-related form of Latanoprost (HY-B0577). Latanoprost lactone diol is significantly upregulated in hypothyroid rats, and its level can be reversed by crude polysaccharide, lactone and oligosaccharide fractions from the rhizome of Atractylodis macrocephalae. Latanoprost lactone diol can be used in studies related to hypothyroidism.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 145667-75-0
- Formula: C18H24O4
- Molecular Weight:304.38
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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FP |
Latanoprost lactone diol (2 μM) does not affect the viability of U251 glioma cells, nor can it induce the translocation of Bax to mitochondria.[1]
Latanoprost lactone diol is a significantly up-regulated differential metabolite in hypothyroidism models; after intervention with Atractylodes macrocephala (especially the polysaccharide CPF fraction and lactone LAF fraction), its abnormally elevated level is reversed[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 145667-75-0
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Appearance Solid
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Molecular Weight 304.38
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Formula C18H24O4
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Color White to off-white
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SMILES
O=C1C[C@@]([C@@H](CC[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C3)([H])[C@@]3([H])O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (328.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Lalier L, et al. Prostaglandins antagonistically control Bax activation during apoptosis. Cell Death Differ. 2011;18(3):528-537. [Content Brief]
[2]. Chen J, et al. Application of Proteomics and Metabonomics to Reveal the Molecular Basis of Atractylodis Macrocephalae Rhizome for Ameliorating Hypothyroidism Instead of Hyperthyroidism. Front Pharmacol. 2021;12:664319. Published 2021 Apr 20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.2854 mL | 16.4268 mL | 32.8537 mL | 82.1342 mL |
| 5 mM | 0.6571 mL | 3.2854 mL | 6.5707 mL | 16.4268 mL | |
| 10 mM | 0.3285 mL | 1.6427 mL | 3.2854 mL | 8.2134 mL | |
| 15 mM | 0.2190 mL | 1.0951 mL | 2.1902 mL | 5.4756 mL | |
| 20 mM | 0.1643 mL | 0.8213 mL | 1.6427 mL | 4.1067 mL | |
| 25 mM | 0.1314 mL | 0.6571 mL | 1.3141 mL | 3.2854 mL | |
| 30 mM | 0.1095 mL | 0.5476 mL | 1.0951 mL | 2.7378 mL | |
| 40 mM | 0.0821 mL | 0.4107 mL | 0.8213 mL | 2.0534 mL | |
| 50 mM | 0.0657 mL | 0.3285 mL | 0.6571 mL | 1.6427 mL | |
| 60 mM | 0.0548 mL | 0.2738 mL | 0.5476 mL | 1.3689 mL | |
| 80 mM | 0.0411 mL | 0.2053 mL | 0.4107 mL | 1.0267 mL | |
| 100 mM | 0.0329 mL | 0.1643 mL | 0.3285 mL | 0.8213 mL |
Latanoprost lactone diol Related Classifications
HY-125946 Related Classifications
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