2. GPCR/G Protein
    Metabolic Enzyme/Protease
    Autophagy
    Apoptosis
  3. Prostaglandin Receptor
    Endogenous Metabolite
    Autophagy
    Apoptosis
  4. Dinoprost

Dinoprost  (Synonyms: Prostaglandin F2α; PGF2α)

Cat. No.: HY-12956 Purity: ≥98.0%
COA Handling Instructions

Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.

For research use only. We do not sell to patients.

Dinoprost Chemical Structure

Dinoprost Chemical Structure

CAS No. : 551-11-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid or liquid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 66 In-stock
Estimated Time of Arrival: December 31
Solid or liquid
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
25 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 440 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour[1][2].

IC50 & Target

FP Receptor

 

Human Endogenous Metabolite

 

In Vitro

Dinoprost (Prostaglandin F2α; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells[1].
Dinoprost (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: Significantly increased the apoptotic rate (15.62±3.12%).

Cell Autophagy Assay[1]

Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.

Western Blot Analysis[1]

Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.
Clinical Trial
Molecular Weight

354.48

Appearance

<25°C Solid,>35°C Liquid

Formula

C20H34O5
CAS No.
SMILES
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (282.10 mM; Need ultrasonic)

H2O : 100 mg/mL (282.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8210 mL 14.1052 mL 28.2103 mL
5 mM 0.5642 mL 2.8210 mL 5.6421 mL
10 mM 0.2821 mL 1.4105 mL 2.8210 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Dinoprost551-11-1Prostaglandin F2α PGF2αProstaglandin ReceptorEndogenous MetaboliteAutophagyApoptosisluteolytichormoneluminalepitheliumcorpusluteumlabourERstressInhibitorinhibitorinhibit

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