2. GPCR/G Protein Metabolic Enzyme/Protease Autophagy Apoptosis
  3. Prostaglandin Receptor Endogenous Metabolite Autophagy Apoptosis
  4. Dinoprost tromethamine salt

Dinoprost tromethamine salt  (Synonyms: Prostaglandin F2α tromethamine salt; PGF2α THAM; Prostaglandin F2α THAM)

Cat. No.: HY-12956A Purity: 98.0%
COA
SDS
Handling Instructions Technical Support

Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 38562-01-5

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 9 publication(s) in Google Scholar

Other Forms of Dinoprost tromethamine salt:

Dinoprost tromethamine salt Related Antibodies

Top Publications Citing Use of Products

    Dinoprost tromethamine salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866.  [Abstract]

    Dinoprost (20 mg/kg/d for 10 days, intraperitoneally injected). Representative images of MBP and LFB staining (scale bar, 500 μm) (n = 6), and transmission electron microscopy (scale bar, 1 μm) (n = 6) in the corpus callosum region of different groups of mice.

    Dinoprost tromethamine salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866.  [Abstract]

    Dinoprost (20 mg/kg/d for 10 days, intraperitoneally injected). Expression of SLC2A4 and MBP in the mouse corpus callosum determined and statistically analyzed by protein immunoblotting.

    Dinoprost tromethamine salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866.  [Abstract]

    Dinoprost (20 mg/kg/d for 10 days, intraperitoneally injected). Expression of SLC2A4 and MBP in the mouse corpus callosum determined and statistically analyzed by real-time PCR.

    Dinoprost tromethamine salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866.  [Abstract]

    LPS+ATP-induced pyroptosis treated with EVO (at different concentrations) and SLC2A4 inhibitor Dinoprost (PGF2α, 1 μM, 24 h) followed by eGFP-mCherry probe detection of autophagic flux (scale bar, 20 μm) and fluorescence detection of SLC2A4 (scale bar, 50 μm): LAMP1 (green), LC3B (red), and DAPI (blue) (scale bar, 50 μm).

    Dinoprost tromethamine salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866.  [Abstract]

    Western blot analysis of pyroptotic proteins GSDMD, GSDMD-N, and NLRP3 inflammasome expression after LPS+ATP induced-pyroptosis, and EVO and SLC2A4 inhibitor Dinoprost (PGF2α, 1 μM, 24 h) treatment.

    Dinoprost tromethamine salt purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May 14:143:156866.  [Abstract]

    Expressions of autophagy-related proteins P62, Beclin1, and LC3B detected by western blot after LPS+ATP induced-pyroptosis, and EVO and SLC2A4 inhibitor PGF2α treatment.

    View All Prostaglandin Receptor Isoform Specific Products:

    View All Isoforms
    DP EP FP IP TXA2/TP TXB2

    View All Endogenous Metabolite Isoform Specific Products:

    View All Isoforms
    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • 순도&문서

    • References

    • 고객리뷰

    제품 설명

    Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour[1][2].

    IC50 & Target[1][2]

    FP Receptor

     

    Human Endogenous Metabolite

     

    In Vitro

    Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells[1].
    Dinoprost tromethamine salt (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Dinoprost tromethamine salt Related Antibodies

    Apoptosis Analysis[1]

    Cell Line: Goat luteal cells
    Concentration: 1 μM
    Incubation Time: For 24 hours
    Result: Significantly increased the apoptotic rate (15.62±3.12%).

    Cell Autophagy Assay[1]

    Cell Line: Goat luteal cells
    Concentration: 1 μM
    Incubation Time: For 24 hours
    Result: There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.

    Western Blot Analysis[1]

    Cell Line: Goat luteal cells
    Concentration: 1 μM
    Incubation Time: For 24 hours
    Result: The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.
    분자량

    475.62

    화학식

    C24H45NO8
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(O)=O.OCC(CO)(N)CO
    Structure Classification
    Initial Source
    선적

    Room temperature in continental US; may vary elsewhere.
    보관

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    용액&용해도
    In Vitro: 

    H2O : ≥ 100 mg/mL (210.25 mM)

    DMSO : ≥ 100 mg/mL (210.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1025 mL 10.5126 mL 21.0252 mL
    5 mM 0.4205 mL 2.1025 mL 4.2050 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • 몰농도 계산기

    • 농도 희석 계산기

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (105.13 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    순도&문서
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.1025 mL 10.5126 mL 21.0252 mL 52.5630 mL
    5 mM 0.4205 mL 2.1025 mL 4.2050 mL 10.5126 mL
    10 mM 0.2103 mL 1.0513 mL 2.1025 mL 5.2563 mL
    15 mM 0.1402 mL 0.7008 mL 1.4017 mL 3.5042 mL
    20 mM 0.1051 mL 0.5256 mL 1.0513 mL 2.6281 mL
    25 mM 0.0841 mL 0.4205 mL 0.8410 mL 2.1025 mL
    30 mM 0.0701 mL 0.3504 mL 0.7008 mL 1.7521 mL
    40 mM 0.0526 mL 0.2628 mL 0.5256 mL 1.3141 mL
    50 mM 0.0421 mL 0.2103 mL 0.4205 mL 1.0513 mL
    60 mM 0.0350 mL 0.1752 mL 0.3504 mL 0.8760 mL
    80 mM 0.0263 mL 0.1314 mL 0.2628 mL 0.6570 mL
    100 mM 0.0210 mL 0.1051 mL 0.2103 mL 0.5256 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Dinoprost tromethamine salt Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dinoprost38562-01-5Prostaglandin F2α PGF2α THAM Prostaglandin F2α THAMProstaglandin ReceptorEndogenous MetaboliteAutophagyApoptosisluteolytichormoneluminalepitheliumcorpusluteumlabourERstressInhibitorinhibitorinhibit

    최근 본 상품:

    온라인 문의

    Your information is safe with us. * Required Fields.

    상품명

    		  

    Requested Quantity *

    고객명 *

    		 

    호칭

    메일주소 *

    		 

    전화번호 *

    Department

    		 

    회사명 *

    City

    도

    Country or Region *

    		      

    비고

    대량구매 문의

    Inquiry Information

    상품명:
    Dinoprost tromethamine salt
    Cat. No.:
    HY-12956A
    수량:
    MCE Japan Authorized Agent:

    고객리뷰

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    상품명

    		  

    Lot #

    고객명 *

    		 

    메일주소 *

    전화번호

    		 

    Department *

    회사명 *

    		 

    Country or Region *

    비고

    SAFETY DATA SHEET (SDS)

    English - EN (557 KB) Français - FR (557 KB) Deutsch - DE (557 KB) Norwegian - NO (557 KB) Español - ES (557 KB) Swedish - SV (557 KB) Italian - IT (557 KB) Korean - KR (557 KB) Portuguese - PT (557 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.