1. GPCR/G Protein
  2. Prostaglandin Receptor

Prostaglandin E1 (Synonyms: PGE1)

Cat. No.: HY-B0131 Purity: >98.0%
Data Sheet SDS Handling Instructions

Prostaglandin E1 (Alprostadil) is a prostaglandin, which is used in the treatment of erectile dysfunction and has vasodilatory properties.

For research use only. We do not sell to patients.
Prostaglandin E1 Chemical Structure

Prostaglandin E1 Chemical Structure

CAS No. : 745-65-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $66 In-stock
5 mg $60 In-stock
10 mg $90 In-stock
50 mg $350 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Prostaglandin E1 (Alprostadil) is a prostaglandin, which is used in the treatment of erectile dysfunction and has vasodilatory properties. Target: Prostaglandin Receptor Prostaglandin E1 (PGE1), known pharmaceutically as alprostadil, is a prostaglandin. It is a drug used in the treatment of erectile dysfunction and has vasodilatory properties. In healthy humans, prostaglandin E1 is biosynthesized "on demand" at its intended site of action from dihomo-γ-linolenic acid. Alprostadil is a naturally occurring prostaglandin used in the treatment of infants with congenital heart defects to maintain the patency of the ductus arteriosus until palliative or corrective surgery can be performed. In infants with defects restricting pulmonary blood flow (cyanotic), alprostadil improves arterial blood oxygenation. In infants with defects restricting systemic blood flow, alprostadil improves arterial blood pH, urine output, and femoral arterial pulses. Alprostadil is administered by continuous intraarterial or intravenous infusion, usually at a starting dose of 0.1 microgram/kg/min, with maintenance doses as low as 0.002 microgram/kg/min.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01245855 First Affiliated Hospital, Sun Yat-Sen University Prostaglandin E1|Percutaneous Coronary Intervention January 2011 Phase 3
NCT03159559 Tongji Hospital Coronary Microvascular Perfusion in Patients With Ischemic Heart Disease January 2017 Phase 4
NCT02628106 West China Hospital Diabetic Nephropathy December 2015 Phase 4
NCT01467076 NICHD Neonatal Research Network|National Center for Research Resources (NCRR)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Prematurity|Respiratory Insufficiency|Pulmonary Hypertension|Respiratory Distress Syndrome, Newborn November 2011 Phase 2
NCT02223949 Hillel Yaffe Medical Center Obesity|Labor Complications October 2014 Phase 2|Phase 3
NCT00314548 Aga Khan University|Medical Research Council, Pakistan Adult Respiratory Distress Syndrome|Pulmonary Hypertension May 2006
NCT00733434 National Taiwan University Hospital Microsurgery|Head and Neck|Prostaglandin E1|Thrombosis|Complications July 2008 Phase 4
NCT01263925 UCB Pharma Stage II Peripheral Arterial Occlusive Disease|Intermittent Claudication Fontaine Stage II PAOD April 2001 Phase 3
NCT00619229 UCB Pharma Macular Degeneration July 2006 Phase 3
NCT00598429 NICHD Neonatal Research Network|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Infant, Newborn|Respiratory Insufficiency|Pulmonary Hypertension|Respiratory Distress Syndrome, Newborn|Streptococcal Infections May 2008 Phase 2
NCT00053716 Endovasc Peripheral Vascular Disease February 2003 Phase 2
NCT02338440 Seoul National University Hospital Veno-occlusive Disease|Child January 2015 Phase 2|Phase 3
NCT02574338 Nwali Matthew Igwe|Federal Teaching Hospital Abakaliki Cervical Ripening September 2015
NCT00955929 Memorial Sloan Kettering Cancer Center|Pfizer Penile Cancer|Erectile Dysfunction|Radical Prostatectomy August 2009
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References
Molecular Weight

354.48

Formula

C₂₀H₃₄O₅

CAS No.

745-65-3

Storage

Powder4°C, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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Prostaglandin E1
Cat. No.:
HY-B0131
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