1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Prostaglandin Receptor
    Endogenous Metabolite
  3. Prostaglandin E1

Prostaglandin E1 (Synonyms: Alprostadil; PGE1)

Cat. No.: HY-B0131 Purity: ≥98.0%
Handling Instructions

Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases.

For research use only. We do not sell to patients.

Prostaglandin E1 Chemical Structure

Prostaglandin E1 Chemical Structure

CAS No. : 745-65-3

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5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 420 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Prostaglandin E1:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

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Description

Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Prostaglandin E1 (1 nM-10 μM; 48 h) concentration-dependently reduces HUVECs proliferation (up to 100% inhibition) in the presence of VEGF (20 ng/mL), with an IC50 of 400 nM[2].
Prostaglandin E1 (0.01-10 μM; 6 h) inhibits VEGF-induced HUVECs migration in a concentration dependent manner, with an IC50 of 500 nM[2].
Prostaglandin E1 (1-5 μM; 12-18 h) inhibits in vitro angiogenesis[2].
Prostaglandin E1 (0.01-10 μM; 20 min) increases intracellular cAMP levels in HUVECs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Prostaglandin E1 (20 ng/animal/day; s.c. for 4 days) significantly inhibits the FGF-induced angiogenesis in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/bl6 female mice (6-8 weeks) were injected with Matrigel supplemented with aFGF and heparin[2]
Dosage: 20 ng/day/animal
Administration: Minipump placed subcutaneously for 4 days
Result: Visibly reduced the neovascularization process.
Clinical Trial
Molecular Weight

354.48

Formula

C₂₀H₃₄O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (282.10 mM; Need ultrasonic)

DMSO : 100 mg/mL (282.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8210 mL 14.1052 mL 28.2103 mL
5 mM 0.5642 mL 2.8210 mL 5.6421 mL
10 mM 0.2821 mL 1.4105 mL 2.8210 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.03%

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Product Name:
Prostaglandin E1
Cat. No.:
HY-B0131
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