Prostaglandin E1  (Synonyms: Alprostadil; PGE1)

Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases^[1][2][3].

Prostaglandin E1 (1 nM-10 μM; 48 h) concentration-dependently reduces HUVECs proliferation (up to 100% inhibition) in the presence of VEGF (20 ng/mL), with an IC₅₀ of 400 nM^[2].
? Prostaglandin E1 (0.01-10 μM; 6 h) inhibits VEGF-induced HUVECs migration in a concentration dependent manner, with an IC₅₀ of 500 nM^[2].
? Prostaglandin E1 (1-5 μM; 12-18 h) inhibits in vitro angiogenesis^[2].
? Prostaglandin E1 (0.01-10 μM; 20 min) increases intracellular cAMP levels in HUVECs^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Prostaglandin E1 (20 ng/animal/day; s.c. for 4 days) significantly inhibits the FGF-induced angiogenesis in mice^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

354.48

Solid

C₂₀H₃₄O₅

745-65-3

CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(O)=O

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

• [1]. Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.  [Content Brief]

  [2]. Cattaneo MG, et, al. Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assay. Br J Pharmacol. 2003 Jan;138(2):377-85.  [Content Brief]

  [3]. Hauck EW, et, al. Prostaglandin E1 long-term self-injection programme for treatment of erectile dysfunction--a follow-up of at least 5 years. Andrologia. 1999;31 Suppl 1:99-103.  [Content Brief]