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Results for "

EP3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (1) Bacterial (1) Drug Metabolite (1) Endogenous Metabolite (4) Fungal (1) Isotope-Labeled Compounds (1) Prostaglandin Receptor (30) Small Interfering RNA (siRNA) (1) TGF-beta/Smad (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (6) Endocrinology (16) Infection (1) Inflammation/Immunology (7) Metabolic Disease (4) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147226

EP3 antagonist 3	Prostaglandin Receptor	Neurological Disease Endocrinology
EP3 antagonist 3 (compound 2) is an orally active, potent and selective *EP3* antagonist, with a pK_i of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research .

HY-P5702

*EP3*	Bacterial Apoptosis Fungal	Infection
EP3 is an antimicrobial peptide. EP3 has antibacterial and antifungal activities. EP3 inhibits E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena with a MIC value of 12.85 μg/mL. EP3 also shows antitumor activity against cancer cells, and induces cell apoptosis .

HY-157496

EP3 antagonist 7	Prostaglandin Receptor	Others
EP3 antagonist 7 (Compound II) is an *EP3* receptor antagonist. EP3 antagonist 7 can be used in the study of itching, pain, dysuria or stress disorders .

HY-157495

EP3 antagonist 6	Prostaglandin Receptor	Endocrinology
EP3 antagonist 6 (compound 5) is a potent, orally and selective EP3 receptor antagonist, with an IC₅₀ of 1.9 nM. EP3 antagonist 6 can inhibits PGE2-induced (HY-101952) uterine contraction in pregnant rats .

HY-153256

EP3 antagonist 4	Prostaglandin Receptor	Metabolic Disease
EP3 antagonist 4 (Compound 28) is an *EP3* antagonist, with a K_i value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes .

HY-157494

EP3 antagonist 5

Prostaglandin Receptor Others

EP3 antagonist 5 (Compound 22) is an EP3 receptor antagonist with an IC₅₀ value of 67 nM .

EP3 antagonist 5	Prostaglandin Receptor	Others
EP3 antagonist 5 (Compound 22) is an *EP3* receptor antagonist with an IC₅₀ value of 67 nM .

HY-106054

Nocloprost	Prostaglandin Receptor	Metabolic Disease Inflammation/Immunology
Nocloprost, a prostaglandin E2 (PGE2) analog, is an orally active EP1- and *EP3-receptor* agonist. Nocloprost inhibits evoked [ ³H]ACh release. Nocloprost has gastroprotective and ulcer-healing properties. Nocloprost accelerates the healing of chronic gastric ulcerations and enhances mucosal growth in rats .

HY-118820

MB-28767

M&B 28767
Prostaglandin Receptor Inflammation/Immunology

MB-28767 (M&B 28767) is an EP₃ receptor agonist .
HY-19361

L-826266

L-826266 is a selective and competitive EP3 receptor antagonist. L-826266 can be used for convulsive disorders research .

MB-28767 M&B 28767	Prostaglandin Receptor	Inflammation/Immunology
MB-28767 (M&B 28767) is an *EP₃* receptor agonist .

L-826266
L-826266 is a selective and competitive EP3 receptor antagonist. L-826266 can be used for convulsive disorders research .

HY-136696

11-Deoxy-16,16-dimethyl-PGE2	Prostaglandin Receptor	Metabolic Disease
11-Deoxy-16,16-dimethyl-PGE2, a Prostaglandin E2 analog, is a EP2 and EP3 receptors agonist. 11-Deoxy-16,16-dimethyl-PGE2 protects proximal renal tubular epithelial cells from potent nephrotoxicity-induced cell damage by exerting anti-oxidative stress .

HY-B0131

Prostaglandin E1 Maximum Cited Publications 9 Publications Verification Alprostadil; PGE1	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases ^[3].

HY-10418

AH 6809 2 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
AH 6809 is an antagonist of EP and DP receptor, with K_is of 1217, 1150, 1597, and 1415 nM for the cloned human EP₁, EP₂, *EP₃-III, and DP receptor* respectively. AH 6809 has a K_i of 350 nM for mouse EP₂ receptor ^[3].

HY-118609

EP4 receptor agonist 2	Prostaglandin Receptor	Inflammation/Immunology
EP4 receptor agonist 2 (compound 31) a potent EP4 receptor agonist with an EC₅₀ value of 0.8 nM; K_i values of >100000, 38000, 3.1 nM for EP2, EP3, EP4 respectively .

HY-15274

L-798106 CM9; GW671021	Prostaglandin Receptor	Cancer
L-798106 is potent and highly selective *prostanoid EP₃* receptor** antagonist (K_i=0.3 nM), it also has micromolar activities at the EP₄, EP₁ and EP₂ receptors with K_i values of 916 nM, >5000 nM and >5000 nM, respectively .

HY-137574

19(R)-Hydroxy prostaglandin E1 19(R)-Hydroxy PGE1	Prostaglandin Receptor	Others
19(R)-Hydroxy prostaglandin E1 (19(R)-Hydroxy PGE1), the major prostaglandin in primate semen, is an agonist of EP1 and EP3 receptor subtypes and exhibits contractile activity on smooth muscle preparations .

HY-19360

Sulprostone SHB 286; CP-34089; ZK-57671
Sulprostone (SHB 286) is a potent and selective EP3 receptor agonist. Sulprostone (SHB 286) is a prostaglandin E2 (PGE2) analogue and has antiulcer and nonsteroidal abortifacient effects. Sulprostone has potential for the research of pregnancy termination and hemorrhages during delivery ^[3].

HY-108563

SC 51089	Prostaglandin Receptor	Neurological Disease
SC 51089 is a selective antagonist of prostaglandin E₂ EP1 receptor, with K_is of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, *EP3, and FP receptors*, respectively. SC 51089 exhibits neuroprotective activity ^[3].

HY-16978

TG6-10-1 5+ Cited Publications	5-HT Receptor Prostaglandin Receptor	Neurological Disease Endocrinology
TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors .

HY-10835

DG-041 2 Publications Verification	Prostaglandin Receptor	Cardiovascular Disease
DG-041 is a potent, high affinity and selective EP₃ receptor antagonist with IC₅₀s of 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively. DG-041 inhibits PGE2 facilitation of platelet aggregation. DG-041 crosses the blood-brain barrier .

HY-108563A

SC 51089 free base	Prostaglandin Receptor	Neurological Disease
SC 51089 free base is a selective antagonist of prostaglandin E₂ EP1 receptor, with K_is of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, *EP3, and FP receptors*, respectively. SC 51089 free base exhibits neuroprotective activity ^[3].

HY-10797

CJ-42794 1 Publications Verification CJ-042794	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
CJ-42794 (CJ-042794) is a potent, orally active, selective prostaglandin E receptor 4 (EP4) antagonist with an IC₅₀ value of 10 nM, which is 200-fold more selective than EP1, EP2 and *EP3*. CJ-42794 can be used in research of gastric ulcers .

HY-100448A

Butaprost	Prostaglandin Receptor TGF-beta/Smad	Endocrinology
Butaprost is a selective prostaglandin E receptor (EP2) agonist with an EC₅₀ of 33 nM and a K_i of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling ^[3].

HY-50901

ONO-AE3-208 Maximum Cited Publications 9 Publications Verification AE 3-208	Prostaglandin Receptor	Endocrinology Cancer
ONO-AE3-208 is a selective and orally active EP4 receptor antagonist with a K_i of 1.3 nM. ONO-AE3-208 shows less potently affects EP3, FP, and TP receptors (K_i of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 suppresses cell invasion, migration, and metastasis of prostate cancer .

HY-B0131S2

Prostaglandin E1-d9 Alprostadil-d₉; PGE1-d₉	Isotope-Labeled Compounds Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-14899

Taprenepag 3 Publications Verification CP-544326	Prostaglandin Receptor	Endocrinology
Taprenepag (CP-544326) is a potent and selective prostaglandin EP(2) agonist with IC₅₀s of 10 and 15 nM for human and rat EP2, respectively. Taprenepag shows selectivity for EP2 over other EP receptors (IC50s>3200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors .

HY-133123

EP4 receptor antagonist 1	Prostaglandin Receptor	Inflammation/Immunology Cancer
EP4 receptor antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist for cancer immunotherapy. EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC₅₀s of 6.1 nM and 16.2 nM, respectively. IC₅₀s >10 μM for human EP1, EP2,and EP3 receptors .

HY-128039

17-Phenyl-ω-trinor-PGE2	Prostaglandin Receptor	Others
17-Phenyl-ω-trinor-PGE2 is a PGE2 (HY-101952) analog, which is an agonist for EP1 and *EP3* receptor. 17-Phenyl-ω-trinor-PGE2 inhibits the PAF-induced aggregation of human platelet-rich plasma (PRP) and Cicaprost (HY-19583) induced Cyclic AMP (HY-B1511) production .

HY-128686

KAG-308 1 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a K_i and an EC₅₀ of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor .

HY-B0601

Tafluprost acid 1 Publications Verification AFP-172	Prostaglandin Receptor Drug Metabolite	Cardiovascular Disease Neurological Disease Endocrinology
Tafluprost acid (AFP-172), an active metabolic form of Tafluprost, is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with K_i and EC₅₀ values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for *prostanoid EP3* receptor (IC₅₀**=67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma ^[3].

HY-B0131S

Prostaglandin E1-d4	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].

HY-118743

KMN-80	Prostaglandin Receptor	Metabolic Disease
KMN-80, a derivative of PGE1 (HY-B0131), is a selective and potent agonist of EP₄ receptor with an IC₅₀ and a K_i of 3 nM and 2.35 nM, respectively. KMN-80 is against EP₃ receptor with an IC₅₀ of 1.4 μM and >10 μM for all other prostanoid receptors . KMN-80 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0131R

Prostaglandin E1 (Standard) Alprostadil(Standard); PGE1 (Standard)	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases ^[3].

HY-18971

TG4-155 1 Publications Verification
TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a K_i of 9.9 nM . TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1 . TG4-155 has an EP2 Schild K_B of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor .

HY-B0813

Treprostinil diethanolamine UT-15C
Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with K_i values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries ^[3].

HY-RS02304

CDC42EP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDC42EP3 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC42EP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDC42EP3 Human Pre-designed siRNA Set A CDC42EP3 Human Pre-designed siRNA Set A

HY-B0584

Travoprost 2 Publications Verification Fluprostenol isopropyl ester; AL6221; Flu-Ipr	Prostaglandin Receptor	Endocrinology
Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension .

HY-B0584A

5,6-trans-Travoprost 5,6-trans-Fluprostenol isopropyl ester; 5,6-trans-AL6221; 5,6-trans-Flu-Ipr	Others	Endocrinology
5,6-trans-Travoprost is the isomer of Travoprost (HY-B0584), and can be used as an experimental control. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension .

*EP3*	Bacterial Apoptosis Fungal	Infection
EP3 is an antimicrobial peptide. EP3 has antibacterial and antifungal activities. EP3 inhibits E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena with a MIC value of 12.85 μg/mL. EP3 also shows antitumor activity against cancer cells, and induces cell apoptosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0131

Prostaglandin E1 5+ Cited Publications Alprostadil; PGE1	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases ^[3].

HY-P5702

*EP3*	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Bacterial Apoptosis Fungal
EP3 is an antimicrobial peptide. EP3 has antibacterial and antifungal activities. EP3 inhibits E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena with a MIC value of 12.85 μg/mL. EP3 also shows antitumor activity against cancer cells, and induces cell apoptosis .

HY-B0131R

Prostaglandin E1 (Standard) Alprostadil(Standard); PGE1 (Standard)	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases ^[3].

Cat. No.	Product Name	Chemical Structure

HY-B0131S2

Prostaglandin E1-d9
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-B0131S

Prostaglandin E1-d4
Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].

Prostaglandin E1-d4

Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].

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