SC 51089

Cat. No.: HY-108563: FAQs
Data Sheet Handling Instructions

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SC 51089 is a selective antagonist of prostaglandin E₂ EP1 receptor, with K_is of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 exhibits neuroprotective activity.

For research use only. We do not sell to patients.

SC 51089 Chemical Structure

CAS No. : 146033-02-5

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SC 51089 free base In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

EP1

1.3 μM (Ki)

11.2 μM (Ki)

EP3

17.5 μM (Ki)

61.1 μM (Ki)

In Vitro

SC 51089 (5 μM; 24 h) attenuates prostaglandin E2 (PGE2)-induced the death of neuronal cells exposed to t-BuOOH^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SC 51089 (40 μg/kg; infused i.p. for 28 d) ameliorates motor coordination and balance dysfunction and rescues long-term memory deficit in R6/1 mouse model of HD^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of age^[3]
Dosage:	40 μg/kg/day
Administration:	Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system
Result:	Ameliorated motor coordination and balance dysfunction. Rescued long-term memory deficit. Improved the expression of specific synaptic markers. Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus.

Molecular Weight

459.33

Formula

C₂₂H₂₀Cl₂N₄O₃

CAS No.

146033-02-5

SMILES

O=C(N1C2=CC(Cl)=CC=C2OC3=CC=CC=C3C1)NNC(CCC4=CC=NC=C4)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (217.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1771 mL	10.8854 mL	21.7708 mL
5 mM	0.4354 mL	2.1771 mL	4.3542 mL
10 mM	0.2177 mL	1.0885 mL	2.1771 mL

View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Abramovitz M, et, al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. [Content Brief]

[2]. Saleem S, et, al. Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice. J Neurosci Res. 2007 Aug 15;85(11):2433-40. [Content Brief]

[3]. Anglada-Huguet M, et, al. Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease. Mol Neurobiol. 2014 Apr;49(2):784-95. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1771 mL	10.8854 mL	21.7708 mL	54.4271 mL
	5 mM	0.4354 mL	2.1771 mL	4.3542 mL	10.8854 mL
	10 mM	0.2177 mL	1.0885 mL	2.1771 mL	5.4427 mL
	15 mM	0.1451 mL	0.7257 mL	1.4514 mL	3.6285 mL
	20 mM	0.1089 mL	0.5443 mL	1.0885 mL	2.7214 mL
	25 mM	0.0871 mL	0.4354 mL	0.8708 mL	2.1771 mL
	30 mM	0.0726 mL	0.3628 mL	0.7257 mL	1.8142 mL
	40 mM	0.0544 mL	0.2721 mL	0.5443 mL	1.3607 mL
	50 mM	0.0435 mL	0.2177 mL	0.4354 mL	1.0885 mL
	60 mM	0.0363 mL	0.1814 mL	0.3628 mL	0.9071 mL
	80 mM	0.0272 mL	0.1361 mL	0.2721 mL	0.6803 mL
	100 mM	0.0218 mL	0.1089 mL	0.2177 mL	0.5443 mL

SC 51089 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC 51089146033-02-5SC51089SC-51089Prostaglandin ReceptorneuroprotectiveInhibitorinhibitorinhibit

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