2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. SC 51089

SC 51089 

Cat. No.: HY-108563
Handling Instructions

SC 51089 is a selective antagonist of prostaglandin E2 EP1 receptor, with Kis of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 exhibits neuroprotective activity.

For research use only. We do not sell to patients.

SC 51089 Chemical Structure

SC 51089 Chemical Structure

CAS No. : 146033-02-5

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Description

SC 51089 is a selective antagonist of prostaglandin E2 EP1 receptor, with Kis of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 exhibits neuroprotective activity[1][2][3].

IC50 & Target[1]

EP1

 

EP1

1.3 μM (Ki)

TP

11.2 μM (Ki)

EP3

17.5 μM (Ki)

FP

61.1 μM (Ki)

In Vitro

SC 51089 (5 μM; 24 h) attenuates prostaglandin E2 (PGE2)-induced the death of neuronal cells exposed to t-BuOOH[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

SC 51089 (40 μg/kg; infused i.p. for 28 d) ameliorates motor coordination and balance dysfunction and rescues long-term memory deficit in R6/1 mouse model of HD[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of age[3]
Dosage: 40 μg/kg/day
Administration: Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system
Result: Ameliorated motor coordination and balance dysfunction.
Rescued long-term memory deficit.
Improved the expression of specific synaptic markers.
Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus.
Molecular Weight

459.33

Formula

C22H20Cl2N4O3
CAS No.
SMILES

O=C(N1C2=CC(Cl)=CC=C2OC3=CC=CC=C3C1)NNC(CCC4=CC=NC=C4)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (217.71 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1771 mL 10.8854 mL 21.7708 mL
5 mM 0.4354 mL 2.1771 mL 4.3542 mL
10 mM 0.2177 mL 1.0885 mL 2.1771 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SC 51089146033-02-5SC51089SC-51089Prostaglandin ReceptorneuroprotectiveInhibitorinhibitorinhibit

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