SC 51089 free base

Name: SC 51089 free base
Brand: MedChemExpress
SKU: HY-108563A
Rating: 4.5 (1 reviews)

Cat. No.: HY-108563A Purity: 98.64%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SC 51089 free base is a selective antagonist of prostaglandin E₂ EP1 receptor, with K_is of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 free base exhibits neuroprotective activity.

For research use only. We do not sell to patients.

SC 51089 free base Chemical Structure

CAS No. : 146033-03-6

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 110	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 110	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1090	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SC 51089 free base:

SC 51089 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

EP1

1.3 μM (Ki)

11.2 μM (Ki)

EP3

17.5 μM (Ki)

61.1 μM (Ki)

In Vitro

SC 51089 free base (5 μM; 24 h) attenuates prostaglandin E2 (PGE2)-induced the death of neuronal cells exposed to t-BuOOH^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SC 51089 free base (40 μg/kg; infused i.p. for 28 d) ameliorates motor coordination and balance dysfunction and rescues long-term memory deficit in R6/1 mouse model of HD^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of age^[3]
Dosage:	40 μg/kg/day
Administration:	Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system
Result:	Ameliorated motor coordination and balance dysfunction. Rescued long-term memory deficit. Improved the expression of specific synaptic markers. Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus.

Molecular Weight

422.86

Formula

C₂₂H₁₉ClN₄O₃

CAS No.

146033-03-6

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1C2=CC(Cl)=CC=C2OC3=CC=CC=C3C1)NNC(CCC4=CC=NC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (236.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3648 mL	11.8242 mL	23.6485 mL
5 mM	0.4730 mL	2.3648 mL	4.7297 mL
10 mM	0.2365 mL	1.1824 mL	2.3648 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.64%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (256 KB) HNMR (266 KB) RP-HPLC (246 KB) MS (67 KB)

Handling Instructions (2659 KB)

References

[1]. Abramovitz M, et, al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. [Content Brief]

[2]. Saleem S, et, al. Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice. J Neurosci Res. 2007 Aug 15;85(11):2433-40. [Content Brief]

[3]. Anglada-Huguet M, et, al. Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease. Mol Neurobiol. 2014 Apr;49(2):784-95. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3648 mL	11.8242 mL	23.6485 mL	59.1212 mL
	5 mM	0.4730 mL	2.3648 mL	4.7297 mL	11.8242 mL
	10 mM	0.2365 mL	1.1824 mL	2.3648 mL	5.9121 mL
	15 mM	0.1577 mL	0.7883 mL	1.5766 mL	3.9414 mL
	20 mM	0.1182 mL	0.5912 mL	1.1824 mL	2.9561 mL
	25 mM	0.0946 mL	0.4730 mL	0.9459 mL	2.3648 mL
	30 mM	0.0788 mL	0.3941 mL	0.7883 mL	1.9707 mL
	40 mM	0.0591 mL	0.2956 mL	0.5912 mL	1.4780 mL
	50 mM	0.0473 mL	0.2365 mL	0.4730 mL	1.1824 mL
	60 mM	0.0394 mL	0.1971 mL	0.3941 mL	0.9854 mL
	80 mM	0.0296 mL	0.1478 mL	0.2956 mL	0.7390 mL
	100 mM	0.0236 mL	0.1182 mL	0.2365 mL	0.5912 mL