1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. L-826266

L-826266 

Cat. No.: HY-19361 Purity: ≥98.0%
Handling Instructions

L-826266 is a selective and competitive EP3 receptor antagonist. L-826266 can be used for convulsive disorders research.

For research use only. We do not sell to patients.

L-826266 Chemical Structure

L-826266 Chemical Structure

CAS No. : 244101-03-9

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Description

L-826266 is a selective and competitive EP3 receptor antagonist. L-826266 can be used for convulsive disorders research[1].

IC50 & Target[1]

EP3 Receptor

 

In Vitro

In adult rat hippocampal slices, L-826266 (1 μM) prevents the PGE2-induced decrease of Na+,K+-ATPase activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

L-826266 (0.01-1 nmol/site; i.c.v.; once) delays seizures, and increases the latency for clonic and generalized tonic-clonic seizures induced by PTZ[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats (250-300 g) injected with Pentylenetetrazol (PTZ)[1]
Dosage: 0.01 nmol/site, 0.1 nmol/site or 1 nmol/site
Administration: i.c.v.; once
Result: Increased the latency for clonic and generalized tonic-clonic seizures induced by PTZ.
Molecular Weight

570.88

Formula

C₂₇H₂₁BrClNO₄S

CAS No.
SMILES

O=C(NS(=O)(C1=CC(Br)=CC=C1OC)=O)/C=C/C2=CC(Cl)=CC=C2CC3=CC=C4C=CC=CC4=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥98.0%

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Keywords:

L-826266L826266L 826266Prostaglandin ReceptorEP3competitiveconvulsivedisordersInhibitorinhibitorinhibit

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L-826266
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HY-19361
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