Treprostinil diethanolamine
Based on 3 publication(s) in Google Scholar
Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries.
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- Pureté : 99.44%
- CAS No.: 830354-48-8
- Formule: C27H45NO7
- Masse moléculaire:495.65
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Treprostinil diethanolamine
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Activité biologique
Description
IC50 & Target
[1]|
DP1 4.4 nM (Ki) |
EP1 212 nM (Ki) |
EP4 826 nM (Ki) |
EP3 2505 nM (Ki) |
IP 32.1 nM (Ki) |
FP 4680 nM (Ki) |
EP2 3.6 nM (Ki) |
In Vitro
Treprostinil diethanolamine (UT-15C; 0.001-10,000 nM; 60 min; HEK293 cells) has high potency in activating DP1 and EP2 receptors as well as the IP receptor with EC50 values of 0.6 nM, 6.2 nM and 1.9 nM, respectively, 36-fold less active at the EP3 receptor, 95-fold less active at the EP4 and 150-fold less active at the EP1 site than at the IP receptor[1].
Treprostinil diethanolamine (10 μM) increases cAMP accumulation in murine and human hematopoietic stem and progenitor cells (HSPCs) [2].
Treprostinil diethanolamine (10 μM; 2-6 h; PC3 cells) enhances the action of SDF-1 via CXCR4[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Treprostinil diethanolamine (0.15 mg/kg; i.h.; every 8 h; for 10 d; BALB/c mice) increases survival of lethally irradiated recipient mice[2].
Treprostinil diethanolamine (0.1 mg/kg; i.h.; for 24h; male lewis rats) inhibits the mRNA expression of TNF-α and IFN-γ and increases in IL-10 expression[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice[2]
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Dosage:0.15 mg/kg
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Administration:Subcutaneous injection; every 8 hours; for 10 days
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Result:Increased survival of lethally irradiated recipient mice.
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Animal Model:Male lewis rats[3]
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Dosage:0.1 mg/kg
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Administration:Subcutaneous injection; for 24 hours
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Result:Decreased the mRNA expression of TNF-α and IFN-γ and increased the expression of IL-10.
Chemical Information
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CAS No. 830354-48-8
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Appearance Solid
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Masse moléculaire 495.65
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Formule C27H45NO7
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Color White to off-white
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SMILES
O=C(O)COC1=C2C[C@@]3([H])C[C@@H](O)[C@H](CC[C@@H](O)CCCCC)[C@@]3([H])CC2=CC=C1.OCCNCCO
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Synonyms
UT-15C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Large-scale and high-resolution mass spectrometry-based proteomics defines molecular subtypes of nasopharyngeal carcinoma for therapeutic targeting. [Abstract]2026 Jun 23;11(1):244. PMID: 42331772 -
Cell
2023 Dec 7;186(25):5500-5516.e21. PMID: 38016470 -
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (252.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Whittle BJ, et, al. Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. Biochem Pharmacol. 2012 Jul 1;84(1):68-75. [Content Brief]
[3]. Ghonem N, et, al. Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation. Am J Transplant. 2011 Nov;11(11):2508-16. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0176 mL | 10.0878 mL | 20.1755 mL | 50.4388 mL |
| 5 mM | 0.4035 mL | 2.0176 mL | 4.0351 mL | 10.0878 mL | |
| 10 mM | 0.2018 mL | 1.0088 mL | 2.0176 mL | 5.0439 mL | |
| 15 mM | 0.1345 mL | 0.6725 mL | 1.3450 mL | 3.3626 mL | |
| 20 mM | 0.1009 mL | 0.5044 mL | 1.0088 mL | 2.5219 mL | |
| 25 mM | 0.0807 mL | 0.4035 mL | 0.8070 mL | 2.0176 mL | |
| 30 mM | 0.0673 mL | 0.3363 mL | 0.6725 mL | 1.6813 mL | |
| 40 mM | 0.0504 mL | 0.2522 mL | 0.5044 mL | 1.2610 mL | |
| 50 mM | 0.0404 mL | 0.2018 mL | 0.4035 mL | 1.0088 mL | |
| 60 mM | 0.0336 mL | 0.1681 mL | 0.3363 mL | 0.8406 mL | |
| 80 mM | 0.0252 mL | 0.1261 mL | 0.2522 mL | 0.6305 mL | |
| 100 mM | 0.0202 mL | 0.1009 mL | 0.2018 mL | 0.5044 mL |
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