1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Prostaglandin Receptor
    Drug Metabolite
  3. Tafluprost acid

Tafluprost acid  (Synonyms: AFP-172)

Cat. No.: HY-B0601
Handling Instructions

Tafluprost acid (AFP-172), an active metabolic form of Tafluprost, is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma.

For research use only. We do not sell to patients.

Tafluprost acid Chemical Structure

Tafluprost acid Chemical Structure

CAS No. : 209860-88-8

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Description

Tafluprost acid (AFP-172), an active metabolic form of Tafluprost, is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma[1][2][3].

IC50 & Target[1]

Human FP Receptor

0.4 nM (Ki)

Human FP Receptor

0.53 nM (EC50)

In Vitro

Tafluprost acid (10, 100 nM, added on days 0 and 2) significantly inhibits adipogenesis in the early and late stages of differentiation of 3T3-L1 preadipocytes[2].
Tafluprost acid (100 nM, added on day 2 after initiating differentiation) suppresses adipogenesis in wild-type but not in FP knockout mouse primary adipocytes[2].
Tafluprost acid (10-4 M, 6 hours) stimulates the proliferation, migration of human umbilical vascular endothelial cells (HUVECs)[4].
Tafluprost acid (10-4 M, 4-18 hours) stimulates the tube formation of HUVECs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

410.45

Formula

C22H28F2O5

CAS No.
SMILES

O[[email protected]]([[email protected]@H]1C/C=C\CCCC(O)=O)C[[email protected]]([[email protected]@H]1/C=C/C(F)(COC2=CC=CC=C2)F)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tafluprost acid
Cat. No.:
HY-B0601
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