1. GPCR/G Protein
  2. Prostaglandin Receptor

CJ-42794 (Synonyms: CJ-042794)

Cat. No.: HY-10797 Purity: 98.37%
Data Sheet SDS Handling Instructions

CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3).

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CJ-42794 Chemical Structure

CJ-42794 Chemical Structure

CAS No. : 847728-01-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO $55 In-stock
10 mg $50 In-stock
50 mg $170 In-stock
100 mg $300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3). IC50 value: 8.5 (pKi ) [1] Target: EP4 in vitro: CJ-042794 competitively inhibits PGE2-evoked elevations of intracellular cAMP levels in HEK293 cells overexpressing human EP4receptor with a mean pA2 value of 8.6. PGE2 inhibits the lipopolysaccharide (LPS)-induced production of tumor necrosis factor α (TNFα) in human whole blood (HWB); CJ-042794 reverses the inhibitory effects of PGE2 on LPS-induced TNFα production in a concentration-dependent manner. [1] in vivo: CJ-42794 significantly delays the ulcer healing in rats and mice. The expression of VEGF in primary rat gastric fibroblasts was increased by PGE2 or AE1-329 (EP4 agonist), and these responses were both attenuated by coadministration of CJ-42794.[2]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.4165 mL 12.0823 mL 24.1645 mL
5 mM 0.4833 mL 2.4165 mL 4.8329 mL
10 mM 0.2416 mL 1.2082 mL 2.4165 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

413.83

Formula

C₂₂H₁₇ClFNO₄

CAS No.

847728-01-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 28 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
CJ-42794
Cat. No.:
HY-10797
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