11-Deoxy-16,16-dimethyl-PGE2
11-Deoxy-16,16-dimethyl-PGE2, a Prostaglandin E2 analog, is a EP2 and EP3 receptors agonist. 11-Deoxy-16,16-dimethyl-PGE2 protects proximal renal tubular epithelial cells from potent nephrotoxicity-induced cell damage by exerting anti-oxidative stress.
For research use only. We do not sell to patients.
- CAS No.: 53658-98-3
- Formula: C22H36O4
- Molecular Weight:364.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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EP2 |
EP3 |
11-Deoxy-16,16-dimethyl-PGE2, selectively stimulates the synthesis of several proteins in protect renal proximal tubular epithelial (LLC-PK1) cells, including endothelial actin binding protein, myosin, elongation factor 2 (EF-2), elongation factor 1alpha-1 (EF-1alpha), HSP90beta, GRP78, membrane-organizing extension spike protein, and actin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 53658-98-3
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Molecular Weight 364.52
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Formula C22H36O4
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SMILES
CCCCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@H](C(CC1)=O)C/C=C\CCCC(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. R F Parrott, et al. Effects of centrally administered prostaglandin EP receptor agonists on febrile and adrenocortical responses in the prepubertal pig. Brain Res Bull. 1996;41(2):97-103. [Content Brief]
[2]. Kelly M Towndrow, et al. 11-Deoxy,16,16-dimethyl prostaglandin E2 induces specific proteins in association with its ability to protect against oxidative stress. Chem Res Toxicol. 2003 Mar;16(3):312-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
11-Deoxy-16,16-dimethyl-PGE2 Related Classifications
HY-136696 Related Classifications
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