53658-98-3
53658-98-3
Chemical Structure
11-Deoxy-16,16-dimethyl-PGE2
- CAS No.: 53658-98-3
- Formula:C22H36O4
- Molecular Weight:364.52
IUPAC Name: (Z)-7-((1R,2R)-2-((R,E)-3-hydroxy-4,4-dimethyloct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid
InChIKey: LLVVDFDWPQHXBA-QEJIITRLSA-N
SMILES: CCCCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@H](C(CC1)=O)C/C=C\CCCC(O)=O
Biological Activity: 11-Deoxy-16,16-dimethyl-PGE2, a Prostaglandin E2 analog, is a EP2 and EP3 receptors agonist. 11-Deoxy-16,16-dimethyl-PGE2 protects proximal renal tubular epithelial cells from potent nephrotoxicity-induced cell damage by exerting anti-oxidative stress[1][2].
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11-Deoxy-16,16-dimethyl-PGE2 | 11-Deoxy-16,16-dimethyl-PGE2, a Prostaglandin E2 analog, is a EP2 and EP3 receptors agonist. 11-Deoxy-16,16-dimethyl-PGE2 protects proximal renal tubular epithelial cells from potent nephrotoxicity-induced cell damage by exerting anti-oxidative stress. | |||||||||||||||||||||
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References
- [1]. R F Parrott, et al. Effects of centrally administered prostaglandin EP receptor agonists on febrile and adrenocortical responses in the prepubertal pig. Brain Res Bull. 1996;41(2):97-103. [Content Brief]
- [2]. Kelly M Towndrow, et al. 11-Deoxy,16,16-dimethyl prostaglandin E2 induces specific proteins in association with its ability to protect against oxidative stress. Chem Res Toxicol. 2003 Mar;16(3):312-9. [Content Brief]
Keywords
