AH 6809

Cat. No.: HY-10418 Purity: 99.47%: FAQs
Data Sheet SDS COA Handling Instructions

AH 6809 is an antagonist of EP and DP receptor, with K_is of 1217, 1150, 1597, and 1415 nM for the cloned human EP₁, EP₂, EP₃-III, and DP receptor respectively. AH 6809 has a K_i of 350 nM for mouse EP₂ receptor.

For research use only. We do not sell to patients.

AH 6809 Chemical Structure

CAS No. : 33458-93-4

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solution
10 mM * 1 mL in DMSO	USD 85	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 85	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 77	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 121	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 484	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 858	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE AH 6809

Featured Recommendations

•Related Screening Libraries:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

AH 6809 (1 μM; 30 min) inhibits T. serrulatus venom (TsV)-induced and PGE₂-amplified IL-1β and cAMP production in macrophages^[4].
AH 6809 (30-300 μM) antagonizes the anti-aggregatory activity of PGD2 in whole blood, with an apparent pA₂ of 5.35^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AH 6809 (5 mg/kg; i.p.) decreases TsV-induced mortality, PGE₂ and IL-1β production and neutrophil infiltration in the lungs of mice^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

298.29

Appearance

Solid

Formula

C₁₇H₁₄O₅

CAS No.

33458-93-4

SMILES

O=C1C2=C(C=CC(C(O)=O)=C2)OC3=CC(OC(C)C)=CC=C31

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (83.81 mM; Need ultrasonic)

H₂O : 0.1 mg/mL (0.34 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3524 mL	16.7622 mL	33.5244 mL
5 mM	0.6705 mL	3.3524 mL	6.7049 mL
10 mM	0.3352 mL	1.6762 mL	3.3524 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: 2.5 mg/mL (8.38 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: 2.5 mg/mL (8.38 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.47%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (245 KB) LCMS (478 KB)

Handling Instructions (2659 KB)

References

[1]. Abramovitz M, et, al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. [Content Brief]

[2]. Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. [Content Brief]

[3]. Woodward DF, et, al. 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. Biochem Pharmacol. 1995 Nov 9;50(10):1731-3. [Content Brief]

[4]. Zoccal KF, et, al. Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality. Nat Commun. 2016 Feb 23;7:10760. [Content Brief]

[5]. Keery RJ, et, al. AH6809, a prostaglandin DP-receptor blocking drug on human platelets. Br J Pharmacol. 1988 Jul;94(3):745-54. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

AH 680933458-93-4AH6809AH-6809Prostaglandin ReceptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email address *

Phone number *

Organization name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name			Lot #
Applicant Name *			Email address *
Phone number			Department *
Organization name *			Country or Region *
Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

AH 6809

Customer Review

2 Publications Citing Use of MCE AH 6809

Featured Recommendations

•Related Screening Libraries:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

Request for HNMR Report