6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist

  • Biochem Pharmacol. 1995 Nov 9;50(10):1731-3. doi: 10.1016/0006-2952(95)02035-7.
D F Woodward  1 ,  D J Pepperl ,  T H Burkey ,  J W Regan
Affiliations
  • 1. Department of Biosciences (RD-2C), Allergan Inc., Irvine, CA 92713, USA.
PMID: 7503778 DOI: 10.1016/0006-2952(95)02035-7
Abstract

On studying the interaction of various ligands with the pharmacologically defined, recombinant human EP2 receptor (Regan et al., Mol Pharmacol 46: 213-220, 1994), we discovered that the putative EP1 receptor antagonist 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809) also has affinity for the human EP2 receptor. Moreover, AH 6809 behaved as an EP2 receptor antagonist and inhibited prostaglandin E2 (PGE2)-stimulated increases in cyclic AMP. These findings have significant implications for studies that employ AH 6809 to determine the pharmacological basis of PGE2-induced responses in human cells and tissues.

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