1. GPCR/G Protein
  2. Prostaglandin Receptor

Taprenepag (Synonyms: CP-544326)

Cat. No.: HY-14899 Purity: 98.62%
Handling Instructions

CP-544326 is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM) .

For research use only. We do not sell to patients.

Taprenepag Chemical Structure

Taprenepag Chemical Structure

CAS No. : 752187-80-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 264 In-stock
Estimated Time of Arrival: December 31
50 mg USD 792 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Taprenepag:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CP-544326 is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM) . IC50 value: 2.8 nM (EC50) Target: EP2 in vitro: CP-544326 is a novel, selective and potent EP2 agonist. CP-544326 with an IC50 for human EP2 equal to 10 nM (average of two independent experiments; 9 and 11 nM), is at least 270 times more selective for human EP2 subtype as compared with the other human EP subtypes, 1, 3, and 4. Based on the cell-based efficacy data using rat EP2-HEP293 cells, cAMP levels increased in a dose- and time-dependent manner yielding an average EC50of 1.9 nM (1.5 and 2.4 nM; from two independent experiments). In human EP2-HEK293 cells, CP-544326-mediated cAMP production yielded an EC50 of 2.8 nM (2.5 and 3.1 nM; from two independent experiments), which was similar to that observed for PGE2(EC50 = 2.6 nM).

Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (64.78 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0898 mL 10.4489 mL 20.8978 mL
5 mM 0.4180 mL 2.0898 mL 4.1796 mL
10 mM 0.2090 mL 1.0449 mL 2.0898 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

478.52

Formula

C₂₄H₂₂N₄O₅S

CAS No.

752187-80-7

SMILES

O=S(C1=CN=CC=C1)(N(CC2=CC(OCC(O)=O)=CC=C2)CC3=CC=C(N4C=CC=N4)C=C3)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Taprenepag
Cat. No.:
HY-14899
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Taprenepag

Cat. No.: HY-14899