1. GPCR/G Protein
  2. Prostaglandin Receptor

ONO-AE3-208 (Synonyms: AE 3-208)

Cat. No.: HY-50901 Purity: >98.0%
Handling Instructions

ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer.

For research use only. We do not sell to patients.

ONO-AE3-208 Chemical Structure

ONO-AE3-208 Chemical Structure

CAS No. : 402473-54-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 840 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

    ONO-AE3-208 purchased from MCE. Usage Cited in: Hypertension. 2014 Aug;64(2):369-77.

    Effect of EP4 antagonists on AngII-induced PRR protein expression in primary IMCD cells. PRR protein expression is analyzed by immunoblotting. (A and B) Representative PRR immunoblot from 2-3 independent experiments.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References


    ONO-AE3-208 is an EP4 antagonist, and suppresses cell invasion, migration, and metastasis of prostate cancer.

    In Vitro

    ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation[1]. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208[2].

    In Vivo

    ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice[1]. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls[3].

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 45 mg/mL (111.27 mM)

    *"≥" means soluble, but saturation unknown.

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4726 mL 12.3631 mL 24.7262 mL
    5 mM 0.4945 mL 2.4726 mL 4.9452 mL
    10 mM 0.2473 mL 1.2363 mL 2.4726 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      ONO-AE3-208 is prepared in drinking water[4].

    Molecular Weight




    CAS No.




    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month

    Room temperature in continental US; may vary elsewhere

    Purity: >98.0%

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name



    Applicant name *


    Email address *

    Phone number *


    Organization name *

    Country or Region *


    Requested quantity *


    Bulk Inquiry

    Inquiry Information

    Product Name:
    Cat. No.:


    Cat. No.: HY-50901