2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. ONO-AE3-208 sodium salt

ONO-AE3-208 sodium salt  (Synonyms: AE 3-208 sodium salt)

Cat. No.: HY-50901A
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ONO-AE3-208 (sodium salt) is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 (sodium salt) shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 (sodium salt) suppresses cell invasion, migration, and metastasis of prostate cancer.

For research use only. We do not sell to patients.

CAS No. : 2309931-05-1

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Based on 12 publication(s) in Google Scholar

Other Forms of ONO-AE3-208 sodium salt:

ONO-AE3-208 sodium salt Related Antibodies

Top Publications Citing Use of Products

    ONO-AE3-208 sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Res. 2026 Jan 22.  [Abstract]

    BALB/c nude mice intravenously injected with shNC or shACSL5 LM3 cells were administered with PAC, celecoxib, and ONO-AE3-208 (10 mg/kg; p.o.) alone or in combination. Representative images are shown. The results showed that ACSL5 knockdown, celecoxib, ONO-AE3-208, or PAC dramatically mitigated lung metastasis, whereas targeting ACSL5, COX2, or EP4 in combination with PAC led to a more pronounced reduction in lung metastasis.

    ONO-AE3-208 sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Res. 2026 Jan 22.  [Abstract]

    BALB/c nude mice intravenously injected with shNC or shACSL5 LM3 cells were administered with PAC, celecoxib, and ONO-AE3-208 (10 mg/kg; p.o.) alone or in combination. Overall survival are shown. The results showed that ACSL5 knockdown, celecoxib, ONO-AE3-208, or PAC dramatically mitigated lung metastasis, whereas targeting ACSL5, COX2, or EP4 in combination with PAC increased overall survival compared with PAC monotherapy.

    ONO-AE3-208 sodium salt purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Oct 14;22(1):233.  [Abstract]

    Effects of ONO-AE3-208 on the expression of IL1B mRNA in macrophages stimulated with GCM from U251 and T98G cells (n = 3). Macrophages were pre-incubated with ONO-AE3-208 (0.1-5 μM), a selective EP4 receptor antagonist, for 30 min prior to treatment with GCM. After 24 h, IL1B mRNA expression was significantly reduced in macrophages treated with GCM derived from U251 or T98G cells in a dose-dependent manner when EP4 was blocked.

    ONO-AE3-208 sodium salt purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Oct 14;22(1):233.  [Abstract]

    Effects of ONO-AE3-208 (0.5-5 μM; pretreatment for 30 min) on the expression of IL1B protein in macrophages stimulated with GCM from U251 and T98G cells (n = 3). ELISA results showed that ONO-AE3-208 reduced IL-1β secretion by inhibiting the EP4 receptor.

    ONO-AE3-208 sodium salt purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Oct 14;22(1):233.  [Abstract]

    The impact of various concentrations of ONO-AE3-208 on U251 cell proliferation was evaluated in vitro over multiple time points. ONO-AE3-208 showed no direct cytotoxicity toward U251 cells in vitro.

    View All Prostaglandin Receptor Isoform Specific Products:

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    DP EP FP IP TXA2/TP TXB2

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    Description

    ONO-AE3-208 (sodium salt) is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 (sodium salt) shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 (sodium salt) suppresses cell invasion, migration, and metastasis of prostate cancer[1][2].

    Molecular Weight

    426.42

    Formula

    C24H20FN2NaO3
    CAS No.
    SMILES

    FC1=CC=C(C2=CC=CC=C21)C(C)C(NC3=CC(C#N)=CC=C3CCCC(O[Na])=O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    ONO-AE3-208 sodium salt Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ONO-AE3-2082309931-05-1AE 3-208Prostaglandin ReceptorInhibitorinhibitorinhibit

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