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ONO-AE3-208 sodium salt

(Synonyms: AE 3-208 sodium salt)
13 Cited Publications
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Based on 13 publication(s) in Google Scholar

ONO-AE3-208 (sodium salt) is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM. ONO-AE3-208 (sodium salt) shows less potently affects EP3, FP, and TP receptors (Ki of 30 nM, 790 nM, and 2400 nM, respectively). ONO-AE3-208 (sodium salt) suppresses cell invasion, migration, and metastasis of prostate cancer.

For research use only. We do not sell to patients.

  • CAS No.: 2309931-05-1
  • Formula: C24H20FN2NaO3
  • Molecular Weight:426.42
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • ONO-AE3-208 sodium salt Chemical Structure
    ONO-AE3-208 sodium salt Chemical Structure
  • Experimental Validation Results for ONO-AE3-208 sodium salt
  • Experimental Validation Results for ONO-AE3-208 sodium salt
  • Experimental Validation Results for ONO-AE3-208 sodium salt
  • Experimental Validation Results for ONO-AE3-208 sodium salt
  • Experimental Validation Results for ONO-AE3-208 sodium salt
CAS No.: 2309931-05-1
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  • ONO-AE3-208 sodium salt Chemical Structure
    ONO-AE3-208 sodium salt Chemical Structure
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    ONO-AE3-208 sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Res. 2026 Jan 22. [Abstract]

    Customer Validation
     BALB/c nude mice intravenously injected with shNC or shACSL5 LM3 cells were administered with PAC, celecoxib, and ONO-AE3-208 (10 mg/kg; p.o.) alone or in combination. Representative images are shown. The results showed that ACSL5 knockdown, celecoxib, ONO-AE3-208, or PAC dramatically mitigated lung metastasis, whereas targeting ACSL5, COX2, or EP4 in combination with PAC led to a more pronounced reduction in lung metastasis.

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    ONO-AE3-208 sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Res. 2026 Jan 22. [Abstract]

    Customer Validation
     BALB/c nude mice intravenously injected with shNC or shACSL5 LM3 cells were administered with PAC, celecoxib, and ONO-AE3-208 (10 mg/kg; p.o.) alone or in combination. Overall survival are shown. The results showed that ACSL5 knockdown, celecoxib, ONO-AE3-208, or PAC dramatically mitigated lung metastasis, whereas targeting ACSL5, COX2, or EP4 in combination with PAC increased overall survival compared with PAC monotherapy.

  • 1/16

    ONO-AE3-208 sodium salt purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Oct 14;22(1):233. [Abstract]

    Customer Validation
     Effects of ONO-AE3-208 on the expression of IL1B mRNA in macrophages stimulated with GCM from U251 and T98G cells (n = 3). Macrophages were pre-incubated with ONO-AE3-208 (0.1-5 μM), a selective EP4 receptor antagonist, for 30 min prior to treatment with GCM. After 24 h, IL1B mRNA expression was significantly reduced in macrophages treated with GCM derived from U251 or T98G cells in a dose-dependent manner when EP4 was blocked.

  • 1/16

    ONO-AE3-208 sodium salt purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Oct 14;22(1):233. [Abstract]

    Customer Validation
     Effects of ONO-AE3-208 (0.5-5 μM; pretreatment for 30 min) on the expression of IL1B protein in macrophages stimulated with GCM from U251 and T98G cells (n = 3). ELISA results showed that ONO-AE3-208 reduced IL-1β secretion by inhibiting the EP4 receptor.

  • 1/16

    ONO-AE3-208 sodium salt purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Oct 14;22(1):233. [Abstract]

    Customer Validation
     The impact of various concentrations of ONO-AE3-208 on U251 cell proliferation was evaluated in vitro over multiple time points. ONO-AE3-208 showed no direct cytotoxicity toward U251 cells in vitro.

  • ONO-AE3-208 sodium salt