1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Prostaglandin Receptor
  3. TG6-10-1

TG6-10-1 

Cat. No.: HY-16978 Purity: 99.28%
Handling Instructions

TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors[1].

For research use only. We do not sell to patients.

TG6-10-1 Chemical Structure

TG6-10-1 Chemical Structure

CAS No. : 1415716-58-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 840 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    TG6-10-1 purchased from MCE. Usage Cited in: J Cell Physiol. 2018 Nov;233(11):8984-8995.

    Small white follicles (SWFs) are treated with TG6-10-1 or GW627368 and WB are used and gray analysis of PCNA, CDK2, and CCND1.
    • Biological Activity

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    • References

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    Description

    TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors[1].

    IC50 & Target

    EP2[1]

    In Vitro

    TG6-10-1 robustly blocks prostaglandin E2 (PGE2) (10 μM)-induced cAMP accumulation in a concentration-dependent manner in SH-SY5Y cells[2].

    In Vivo

    TG6-10-1 (5 mg/kg; i.p.; 4-30 hours) improves survival, accelerates recovery of lost weight, and improves functional recovery following status epilepticus (SE) [1].

    Animal Model: C57BL/6 mice (pilocarpine-induced SE)[1]
    Dosage: 5 mg/kg
    Administration: Intraperitoneal injection; 4, 21, 30 hours
    Result: A significant increase in survival and accelerating the recovery of lost weight in post-SE mice.
    Molecular Weight

    448.43

    Formula

    C₂₃H₂₃F₃N₂O₄

    CAS No.

    1415716-58-3

    SMILES

    O=C(NCCN1C(C(F)(F)F)=CC2=C1C=CC=C2)/C=C/C3=CC(OC)=C(OC)C(OC)=C3

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (223.00 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2300 mL 11.1500 mL 22.3000 mL
    5 mM 0.4460 mL 2.2300 mL 4.4600 mL
    10 mM 0.2230 mL 1.1150 mL 2.2300 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3 mg/mL (6.69 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 3 mg/mL (6.69 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.28%

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    × = ×
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    Keywords:

    TG6-10-15-HT ReceptorProstaglandin ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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    Product Name:
    TG6-10-1
    Cat. No.:
    HY-16978
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