2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. EP3 antagonist 4

EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes.

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EP3 antagonist 4 Chemical Structure

EP3 antagonist 4 Chemical Structure

CAS No. : 2408297-80-1

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EP3 antagonist 4 Related Antibodies

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Description

EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes[1].

Molecular Weight

577.91

Formula

C22H20Cl3FN4O3S2
CAS No.
SMILES

O=S(NC(NC/C(F)=C1CCCC(C=N2)=C\1N2CC3=C(C=C(C=C3)Cl)Cl)=O)(C4=CC(C)=C(S4)Cl)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EP3 antagonist 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EP3 antagonist 42408297-80-1Prostaglandin Receptordiabetesbeta celldysfunctionratInhibitorinhibitorinhibit

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