Succinyl-Coenzyme A sodium
Based on 5 publication(s) in Google Scholar
Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis).
For research use only. We do not sell to patients.
- Purity: 94%
- CAS No.: 108347-97-3
- Formula: C25H40N7NaO19P3S
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications Citing Use of MedChemExpress (MCE) Succinyl-Coenzyme A sodium
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IP
All Endogenous Metabolite Isoforms
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Biological Activity
Succinyl CoA sodium acts as a substrate for rat liver δ-aminolevulinic acid synthase-1 with a Michaelis constant (Km) of 6-120 μmol/L[2].
Succinyl CoA sodium does not bind to recombinant NLRX1 in an in vitro pull-down assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 108347-97-3
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Appearance Solid
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Formula C25H40N7NaO19P3S
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Color White to off-white
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SMILES
O[C@H]([C@@H]1O[P](O)(O)=O)[C@](O[C@@H]1CO[P](O[P](OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCC(O)=O)=O)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2.[x].[Na]
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Synonyms
Succinyl-CoA sodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Nature
2026 Jan;649(8098):1022-1031. PMID: 41225001 -
Nat Microbiol
2026 Jun;11(6):1662-1676. PMID: 42009759 -
J Nanobiotechnology
SIRT5-modified human umbilical cord mesenchymal stem cells loaded with antioxidant polydopamine nanozyme enhance parpi resistance in ovarian cancer via fatty acid metabolism reprogramming. [Abstract]2025 Jul 4;23(1):485. PMID: 40616128 -
Cell Rep
Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis. [Abstract]2024 Dec 13;43(12):115060. PMID: 39673708
Succinyl-Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Dec 13;43(12):115060. [Abstract]
FLAG-TBK1 was overexpressed in HEK293T cells and immunoprecipitated using an anti-FLAG antibody. The immunoprecipitates were then treated with 2 mM Succinyl-Coenzyme A sodium (succinyl-CoA) for 15 min, followed by detection of TBK1 succinylation. The results showed that succinyl-coenzyme A sodium, a well-known precursor for protein succinylation, markedly induced succinylation of FLAG-tagged TBK1 in vitro.
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bioRxiv
A liquid chromatography-mass spectrometry method to quantify total Coenzyme A concentration and isotopic labeling. [Abstract]2026 May 20:2026.05.19.726225. PMID: 42239474
Solvent & Solubility
H2O : 50 mg/mL (Need ultrasonic and warming)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Bicakci Z. Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis. Medicine (Baltimore). 2015 Mar;94(9):e584. [Content Brief]
[2]. Bonkovsky HL, et al. Porphyrin and heme metabolism and the porphyrias. Compr Physiol. 2013 Jan;3(1):365-401. [Content Brief]
[3]. Zhang Y, et al. Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy. Nature. 2026;649(8098):1022-1031. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)