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Cat. No.: HY-148285

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Succinyl CoA

(Synonyms: Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A)

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis).

For research use only. We do not sell to patients.

CAS No.: 604-98-8
Formula: C₂₅H₄₀N₇O₁₉P₃S
Molecular Weight:867.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Succinyl CoA Chemical Structure

CAS No.: 604-98-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (5)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Succinyl CoA acts as a substrate for rat liver δ-aminolevulinic acid synthase-1 with a Michaelis constant (K_m) of 6-120 μmol/L^[2].
Succinyl CoA does not bind to recombinant NLRX1 in an in vitro pull-down assay^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 604-98-8
Molecular Weight 867.61
Formula C₂₅H₄₀N₇O₁₉P₃S
SMILES

O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCC(O)=O)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
Synonyms

Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Nature

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy. [Abstract]

2026 Jan;649(8098):1022-1031. PMID: 41225001
Nat Microbiol

MoCox6 is a regulator of mitophagy and a druggable target in Magnaporthe oryzae. [Abstract]

2026 Jun;11(6):1662-1676. PMID: 42009759
J Nanobiotechnology

SIRT5-modified human umbilical cord mesenchymal stem cells loaded with antioxidant polydopamine nanozyme enhance parpi resistance in ovarian cancer via fatty acid metabolism reprogramming. [Abstract]

2025 Jul 4;23(1):485. PMID: 40616128
Cell Rep

Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis. [Abstract]

2024 Dec 13;43(12):115060. PMID: 39673708

Succinyl CoA purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Dec 13;43(12):115060. [Abstract]

FLAG-TBK1 was overexpressed in HEK293T cells and immunoprecipitated using an anti-FLAG antibody. The immunoprecipitates were then treated with 2 mM Succinyl-Coenzyme A sodium (succinyl-CoA) for 15 min, followed by detection of TBK1 succinylation. The results showed that succinyl-coenzyme A sodium, a well-known precursor for protein succinylation, markedly induced succinylation of FLAG-tagged TBK1 in vitro.
bioRxiv

A liquid chromatography-mass spectrometry method to quantify total Coenzyme A concentration and isotopic labeling. [Abstract]

2026 May 20:2026.05.19.726225. PMID: 42239474

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bicakci Z, et al. Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis. Medicine (Baltimore). 2015;94(9):e584. [Content Brief]

[2]. Bonkovsky HL, et al. Porphyrin and heme metabolism and the porphyrias. Compr Physiol. 2013 Jan;3(1):365-401. [Content Brief]

[3]. Zhang Y, et al. Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy. Nature. 2026;649(8098):1022-1031. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (5)
Purity & Documentation
References

1/16
1/16

Succinyl CoA purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Dec 13;43(12):115060. [Abstract]

Customer Validation
FLAG-TBK1 was overexpressed in HEK293T cells and immunoprecipitated using an anti-FLAG antibody. The immunoprecipitates were then treated with 2 mM Succinyl-Coenzyme A sodium (succinyl-CoA) for 15 min, followed by detection of TBK1 succinylation. The results showed that succinyl-coenzyme A sodium, a well-known precursor for protein succinylation, markedly induced succinylation of FLAG-tagged TBK1 in vitro.

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Succinyl CoA

Publications Citing Use of MedChemExpress (MCE) Succinyl CoA

All Endogenous Metabolite Isoforms