Succinyl CoA disodium
Based on 1 publication(s) in Google Scholar
Succinyl CoA (Succinyl-coenzyme A) disodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA disodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA disodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA disodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl-Coenzyme A sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis).
For research use only. We do not sell to patients.
- CAS No.: 403982-65-0
- Formula: C25H38N7Na2O19P3S
- Molecular Weight:911.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Succinyl CoA disodium
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Biological Activity
Succinyl CoA disodium acts as a substrate for rat liver δ-aminolevulinic acid synthase-1 with a Michaelis constant (Km) of 6-120 μmol/L[2].
Succinyl CoA disodium does not bind to recombinant NLRX1 in an in vitro pull-down assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 403982-65-0
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Molecular Weight 911.57
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Formula C25H38N7Na2O19P3S
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SMILES
O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCC(O)=O)=O)=O)=O)(O[Na])=O)(O[Na])=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
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Synonyms
Succinyl-coenzyme A disodium; S-(Hydrogen succinyl)coenzyme A disodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
A liquid chromatography-mass spectrometry method to quantify total Coenzyme A concentration and isotopic labeling. [Abstract]2026 May 20:2026.05.19.726225. PMID: 42239474
Purity & Documentation
References
[1]. Bicakci Z, et al. Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis. Medicine (Baltimore). 2015;94(9):e584. [Content Brief]
[2]. Bonkovsky HL, et al. Porphyrin and heme metabolism and the porphyrias. Compr Physiol. 2013 Jan;3(1):365-401. [Content Brief]
[3]. Zhang Y, et al. Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy. Nature. 2026;649(8098):1022-1031. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Succinyl CoA disodium Related Classifications
HY-148285A Related Classifications
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