403982-65-0
Chemical Structure
Succinyl CoA disodium
Synonym(s): Succinyl-coenzyme A disodium; S-(Hydrogen succinyl)coenzyme A disodium
- CAS No.: 403982-65-0
- Formula:C25H38N7Na2O19P3S
- Molecular Weight:911.57
InChIKey: RYXRMWWOTZRVTP-MOFQUYDDSA-L
SMILES: O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCC(O)=O)=O)=O)=O)(O[Na])=O)(O[Na])=O)O[C@H]1N2C=NC3=C(N)N=CN=C32
Biological Activity: Succinyl CoA (Succinyl-coenzyme A) disodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA disodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA disodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA disodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl-Coenzyme A sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis)[1][2][3].
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Succinyl CoA disodium | Succinyl CoA (Succinyl-coenzyme A) disodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA disodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA disodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA disodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl-Coenzyme A sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis). | |||||||||||||||||||||
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- [1]. Bicakci Z, et al. Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis. Medicine (Baltimore). 2015;94(9):e584. [Content Brief]
- [2]. Bonkovsky HL, et al. Porphyrin and heme metabolism and the porphyrias. Compr Physiol. 2013 Jan;3(1):365-401. [Content Brief]
- [3]. Zhang Y, et al. Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy. Nature. 2026;649(8098):1022-1031. [Content Brief]
Keywords
