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UNC4976 

Cat. No.: HY-126327
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UNC4976 is a significantly improved cellularly efficacious chemical probe of CBX7. UNC4976 acts as a positive allosteric modulator (PAM) of CBX7 chromodomain binding to nucleic acids with rapid impacts on both PRC1 occupancy on chromatin and gene expression at Polycomb target genes within cells. UNC4976 results enhanced efficacy across three orthogonal cellular assays by simultaneously antagonizing H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA.

For research use only. We do not sell to patients.

UNC4976 Chemical Structure

UNC4976 Chemical Structure

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Description

UNC4976 is a significantly improved cellularly efficacious chemical probe of CBX7. UNC4976 acts as a positive allosteric modulator (PAM) of CBX7 chromodomain binding to nucleic acids with rapid impacts on both PRC1 occupancy on chromatin and gene expression at Polycomb target genes within cells. UNC4976 results enhanced efficacy across three orthogonal cellular assays by simultaneously antagonizing H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA[1].

Molecular Weight

847.09

Formula

C₄₇H₇₀N₆O₈

SMILES

COC([[email protected]](CO)NC([[email protected]](CCCCN(C)C1C2CCC(C2)C1)NC([[email protected]](CC(C)C)NC([[email protected]](C)NC([[email protected]](CC3=CC=CC=C3)NC(C4=CC=C(C(C)(C)C)C=C4)=O)=O)=O)=O)=O)=O

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Room temperature in continental US; may vary elsewhere

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UNC4976
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HY-126327
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