1. Epigenetics
  2. Histone Methyltransferase
  3. UNC4976

UNC4976 

Cat. No.: HY-126327
Handling Instructions

UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA.

For research use only. We do not sell to patients.

UNC4976 Chemical Structure

UNC4976 Chemical Structure

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Description

UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids. UNC4976 simultaneously antagonizes H3K27me3-specific recruitment of CBX7 to target genes while increasing non-specific binding to DNA and RNA[1].

Molecular Weight

847.09

Formula

C₄₇H₇₀N₆O₈

SMILES

COC([[email protected]](CO)NC([[email protected]](CCCCN(C)C1C2CCC(C2)C1)NC([[email protected]](CC(C)C)NC([[email protected]](C)NC([[email protected]](CC3=CC=CC=C3)NC(C4=CC=C(C(C)(C)C)C=C4)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

UNC4976UNC 4976UNC-4976Histone MethyltransferasePAMpeptidomimeticCBX7chromodomainnucleicacidsH3K27me3DNARNAInhibitorinhibitorinhibit

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UNC4976
Cat. No.:
HY-126327
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