1. Anti-infection
  2. Bacterial
  3. Taniborbactam

Taniborbactam (Synonyms: VNRX-5133)

Cat. No.: HY-109124
Handling Instructions

Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria.

For research use only. We do not sell to patients.

Taniborbactam Chemical Structure

Taniborbactam Chemical Structure

CAS No. : 1613267-49-4

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Description

Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria[1][2].

IC50 & Target

β-lactamase[1]

In Vitro

Taniborbactam (VNRX-5133) has IC50s of 0.5 nM, 2 nM, 0.5 nM, 0.06 nM for KPC-2, OXA-48, VIM-4 of K.pneumoniae strain and VIM-2 of P.aeruginosa strain[2].
Both cefepime/Taniborbactam (10 μg/mL) and meropenem/Taniborbactam combinations are highly active against all six of the NDM-1-producing clinical isolates from K.pneumoniae and E.coli, with MIC ranges of 16-0.25 and 1-0.125 μg/mL, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A single dose of cefepime (32 mg/kg)/Taniborbactam (VNRX-5133; 16 mg/kg; s.c.) achieves >4 log10 reduction in viable bacterial counts in the neutropenic mouse lung infection model against a CTX-M-14-producing strain of K.pneumoniae[2].
Combination of Cefepime (16 mg/kg) and Taniborbactam (16 mg/kg; s.c.; twice-a-day for 7 days) demonstrates >2 log10 reductions in viable bacterial counts in the kidney of the ascending urinary tract infection model against a CTX-M-15-producing strain of E.coli[2].
Taniborbactam has a T1/2 of 0.16 hours, a CL of 618 mL/h/kg, and a Vss of 143 mL/kg for mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

389.25

Formula

C₁₉H₂₈BN₃O₅

CAS No.
SMILES

OC(C1=C(OB(O)[[email protected]@H](NC(C[[email protected]@H]2CC[[email protected]@H](NCCN)CC2)=O)C3)C3=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TaniborbactamVNRX-5133VNRX5133VNRX 5133BacterialReversibleboronicacidspectrumβ-lactamaseKPC-2AmpCOXA-48VIM-2Gram-negativebacteriaInhibitorinhibitorinhibit

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Taniborbactam
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