1. Anti-infection
  2. Fungal
  3. 1-Dodecylimidazole

1-Dodecylimidazole (Synonyms: N-Dodecylimidazole)

Cat. No.: HY-138540
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1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.

For research use only. We do not sell to patients.

1-Dodecylimidazole Chemical Structure

1-Dodecylimidazole Chemical Structure

CAS No. : 4303-67-7

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Description

1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity[1][2][3].

In Vitro

N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase[2].
1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats[2]
Dosage: 150 mg/kg body wt
Administration: By stomach tube; daily for 10 days
Result: Had significantly lower serum cholesterol concentrations than untreated animals.
Molecular Weight

236.40

Formula

C₁₅H₂₈N₂

CAS No.

4303-67-7

SMILES

CCCCCCCCCCCCN1C=CN=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

1-DodecylimidazoleN-DodecylimidazoleFungaldetergentpropertiesacidicconditionstumorsextracellularpHInhibitorinhibitorinhibit

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1-Dodecylimidazole
Cat. No.:
HY-138540
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