Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents

  • J Med Chem. 1987 Aug;30(8):1519-21. doi: 10.1021/jm00391a043.
R A Firestone ,  J M Pisano ,  G M Garrity ,  R A Fromtling ,  S B Zimmerman
PMID: 3302260 DOI: 10.1021/jm00391a043
Abstract

Lysosomotropic detergents, which kill mammalian cells by disrupting lysosomal membranes, have now been found to be antifungals also. All strains in our assay are susceptible. The mode of action is as yet undetermined, but intracellular vacuoles may be the primary targets.

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