2. GPCR/G Protein
  3. Free Fatty Acid Receptor
  4. AZ1729

AZ1729 is a potent free fatty acid 2 receptor (FFA2) activator, acting as a direct allosteric agonist and as a positive allosteric modulator. AZ1729 increases the activity of the endogenously produced short chain fatty acid propionate in Gi-mediated pathways, but not at those transduced by Gq/G11. AZ1729 induces inhibition of isoproterenol-induced lipolysis in mouse adipocytes. AZ1729 also can Induce migration of human neutrophils. AZ1729 can be used for researching the signaling pathways of the physiological roles of FFA2.

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AZ1729 Chemical Structure

AZ1729 Chemical Structure

CAS No. : 2016864-46-1

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Description

AZ1729 is a potent free fatty acid 2 receptor (FFA2) activator, acting as a direct allosteric agonist and as a positive allosteric modulator. AZ1729 increases the activity of the endogenously produced short chain fatty acid propionate in Gi-mediated pathways, but not at those transduced by Gq/G11. AZ1729 induces inhibition of isoproterenol-induced lipolysis in mouse adipocytes. AZ1729 also can Induce migration of human neutrophils. AZ1729 can be used for researching the signaling pathways of the physiological roles of FFA2[1].

IC50 & Target

FFA2[1]
Molecular Weight

369.42

Formula

C18H16FN5OS
CAS No.
SMILES

O=C(NC1=CC=CC(C2=C(C)N=C(NC(N)=N)S2)=C1)C3=CC=C(F)C=C3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AZ1729 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ17292016864-46-1AZ 1729AZ-1729Free Fatty Acid ReceptorFFARFree Fatty AcidAllosteric regulationG proteinHuman neutrophilsMouse adipocytesInhibitorinhibitorinhibit

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