2016864-46-1
Chemical Structure
AZ1729
- CAS No.: 2016864-46-1
- Formula:C18H16FN5OS
- Molecular Weight:369.42
IUPAC Name: 4-fluoro-N-(3-(2-guanidino-4-methylthiazol-5-yl)phenyl)benzamide
InChIKey: HULFYSCAJVTAAR-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C2=C(C)N=C(NC(N)=N)S2)=C1)C3=CC=C(F)C=C3
Biological Activity: AZ1729 is an FFA2/FFAR2 allosteric modulator and Gi-biased signaling enhancer. AZ1729 binds to the FFA2 allosteric site without interacting with the orthosteric site, enhances Gi coupling, and inhibits Gq/G11 coupling. AZ1729 inhibits Isoprenaline (HY-B0468)-induced lipolysis in mouse adipocytes. AZ1729 also induces human neutrophil migration. AZ1729 can be used to study the signaling pathways underlying the physiological roles of FFA2[1][2][3][4].
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AZ1729 | AZ1729 is an FFA2/FFAR2 allosteric modulator and Gi-biased signaling enhancer. AZ1729 binds to the FFA2 allosteric site without interacting with the orthosteric site, enhances Gi coupling, and inhibits Gq/G11 coupling. AZ1729 inhibits Isoprenaline (HY-B0468)-induced lipolysis in mouse adipocytes. AZ1729 also induces human neutrophil migration. AZ1729 can be used to study the signaling pathways underlying the physiological roles of FFA2. | |||||||||||||||||||||
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References
- [1]. Dobhal S, et al. Crossroad Between Gut Microbiome and Ischemic Stroke: Underlying Pathways and Therapeutic Possibilities. Indian journal of microbiology. 2026 Jun;66(3):553-573.
- [2]. Dahlgren C, et al. Neutrophil Signaling That Challenges Dogmata of G Protein-Coupled Receptor Regulated Functions. ACS pharmacology & translational science. 2020 Apr 10;3(2):203-220.
- [3]. Rosli NSA, et al. Short-chain fatty acids: possible regulators of insulin secretion. Molecular and cellular biochemistry. 2023 Mar;478(3):517-530.
- [4]. Bolognini D, et al. A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias. The Journal of biological chemistry. 2016 Sep 02;291(36):18915-31. [Content Brief]
